English to Spanish Medical Genetics

En un artículo titulado "Selective Inhibition of Inflammatory Gene Expression in Activated T Lymphocytes: A Mechanism of Immune Suppression by Thiopurines":

"Since the therapeutic immunosuppression of AZA and 6-MP is evident in the setting of chronic inflammatory diseases, but usually does not predispose to opportunistic infections, we reasoned that these drugs act by selectively affecting activated but not resting immune cells. To test this possibility, we developed an in vitro system of AZA-treated T lymphocytes that models closely the effects of AZA therapy on those cells in vivo. Using a **genome-wide expression profiling approach**, we evaluated the effects of AZA on the expression of genes in both resting and stimulated T lymphocytes. Our results have identified several immune and inflammation-related genes whose up-regulated expression is potently inhibited by thiopurines in activated but not resting T lymphocytes, suggesting potential novel immunosuppressive mechanisms of these drugs."

genome-wide indica "relación con todo el genoma o el ADN completo de un individuo" [Navarro] y se traduce "hologenómico" (Navarro) o "pangenómico" (Igea). Hasta los momentos he colocado "método de elaboración de perfiles de expresión pangenómica", pero no sé si está correcto.

Muchísimas gracias por adelantado