отрицательный эффект/ отрицательное воздействие на биодоступность, связанный с приемом/введением препарата при еде

нарушения всасывания при совместном применении лекарственного/ых средств/а с едой/во время еды

A negative food effect, i.e. a decrease in bioavailability upon the co-administration of compounds together with food, has been attributed particularly with high solubility/low permeability compounds (BCS class III). Different mechanisms have been proposed including intestinal dilution leading to a lower concentration gradient across the intestinal wall as well as binding of the active pharmaceutical ingredient to food components in the intestine and thereby decreasing the fraction of the dose available for absorption. These mechanisms refer primarily to the compound and not to the dosage form.
https://www.ncbi.nlm.nih.gov/pubmed/22782559

негативный эффект приема пищи