English to Spanish Medical Medical (general)

Estoy traduciendo un artículo titulado "Safety, tolerability, and efficacy of metformin extended-release oral antidiabetic therapy in patients with type 2 diabetes: An observational trial in Asia".

"A two-phase hydrophilic polymer matrix is used in the MXR, comprising an outer layer that hydrates to form a gel when exposed to fluid in the GI tract and a particulate inner phase from which metformin elutes gradually by diffusion over the dosing interval. In contrast with MIR, which releases 90% of the drug within 30 min, MXR has longer gastric residence and is absorbed more slowly from the upper GI tract, with 90% release over 10 h, which delays the time to peak concentrations by approximately 4–7 h. Taking MXR with the evening meal **exploits naturally slower GI emptying post-prandially** and at night to prolong absorption and permit once-daily dosing. Pharmacokinetic studies show that MXR once-daily has comparable overall bioavailability to an equivalent twice-daily dose of MIR, but that the **steady-state 24-h plasma profile** of the extended-release (XR) formulation has less pronounced peaks and troughs."

MIR = immediate release metformin
MXR = extended release metformin

Muchas gracias por adelantado.