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Glossary entry

Spanish term or phrase:

tiempo de sueño

English translation:

sleep time

Added to glossary by liz askew
Mar 3, 2011 12:36
13 yrs ago
4 viewers *
Spanish term

tiempo de sueño

Spanish to English Other Chemistry; Chem Sci/Eng
Se trata de un programa analitico de la materia: toxicología y química legal.
Cuando enuncia las unidades de estudio figura lo siguiente:
Tiempo de sueño: modelo experimental para estudiar alguno de los factores que regula la toxicocinetica de las sustancias químicas en los organismos vivos. Es correcto si traduzco el término "tiempo de sueño" como "sleeping/sleep time"? Muchas gracias!
Proposed translations (English)
3 +1 sleep time
5 latent period
4 rest(ing) time
1 dormant period
Change log

Mar 8, 2011 17:00: liz askew Created KOG entry

Discussion

liz askew Mar 3, 2011:
@David, call me anything you like (!!), but I hadn't really gone into the deeper meaning, but had just stuck to the literal approach.
David Brown Mar 3, 2011:
Sleep time Seems a bit of a strange way to conduct experiments on the toxicity of a drug. The longer the sleep time the more powerful the effect, and if they don't wake up their dead?
DLyons Mar 3, 2011:
"Sleep time" seems unlikely. Some more context would help. It might be related to something like "half life" of toxins in organisms? "relaxation time" might also be a possibility.

Proposed translations

+1
2 hrs
Selected

sleep time

see page 40

http://www.accessdata.fda.gov/drugsatfda_docs/nda/2010/20102...

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Note added at 2 hrs (2011-03-03 14:42:17 GMT)
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or

sleeping time

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Note added at 2 hrs (2011-03-03 14:42:58 GMT)
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CONCENTRATION-EFFECT RELATIONSHIPS FOR THE DRUG OF ABUSE J ...
by MA Felmlee - 2010 - Cited by 2 - Related articles
9 Mar 2010 ... The sedative/hypnotic duration of effect (sleep time) of GHB was ... All experiments were conducted in metabolic cages in awake and freely moving rats ..... Data were obtained from the current toxicokinetic/toxicodynamic ...
jpet.aspetjournals.org/content/early/2010/03/09/jpet.109.165381.full.pdf

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Note added at 2 hrs (2011-03-03 14:43:32 GMT)
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[PDF]
Circadin, INN-melatonin
File Format: PDF/Adobe Acrobat - Quick View
14 Feb 2000 ... In humans the most important circadian rhythms is the sleep-wake cycle. ..... hexobarbital and increased the sleeping time of the animals. .... In toxicokinetics, plasma levels of melatonin were analysed in rat studies ...
www.ema.europa.eu/docs/en_GB/document.../WC500026808.pdf

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Note added at 2 hrs (2011-03-03 14:44:32 GMT)
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1 Effects of L-lactate and D-mannitol on γ-Hydroxybutyrate ...
by Q Wang - 2008 - Cited by 4 - Related articles
21 Aug 2008 ... solution and D-mannitol significantly alters GHB toxicokinetics and ..... total sleep time of rats were 3 ą 1, 131 ą 40, and 128 ą 41 minutes, respectively. ... indicating this concentration might represent the wake-up ...
dmd.aspetjournals.org/content/early/2008/08/21/dmd.108.022996.full.pdf

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Note added at 2 hrs (2011-03-03 14:45:01 GMT)
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[PDF]
Ramelteon Takeda Global Research and Development Centre (Europe ...
File Format: PDF/Adobe Acrobat - Quick View
sleep-wake rhythm, regulated by circadian excretion of endogenous melatonin. ..... Potentiation of barbiturate-induced sleep times, similar to the reported ..... Toxicokinetic data indicate a large exposure margin for all neoplastic ...
www.emea.europa.eu/docs/en_GB/document.../WC500064663.pdf

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Note added at 2 hrs (2011-03-03 14:47:26 GMT)
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and see page 8

http://docs.google.com/viewer?a=v&q=cache:PuSmE9HhG8MJ:www.e...

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Note added at 2 hrs (2011-03-03 14:48:37 GMT)
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(WO/2005/103041) TREATMENT OF CNS DISORDERS USING CNS TARGET ...
by D EDGAR - 2005 - Cited by 5 - Related articles
Methods for evaluating these sleep-wake and physiological assessment criteria ..... nonREM onset of action profile, sleep latency, REM sleep time, REM sleep ...
www.wipo.int/pctdb/en/wo.jsp?WO=2005103041&IA... - Cached

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Note added at 2 hrs (2011-03-03 14:53:22 GMT)
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Sleep and benzodiazepine receptor sub-types
by WB Mendelson - 1987 - Cited by 7 - Related articles
of the benzodiazepine receptor complex (Squires and Braestrup, ... Correlation coefficients for sleep latency and total sleep time were 0.996 and ...
www.springerlink.com/index/H3084536W1484R71.pdf - Similar
Peer comment(s):
agree Thayenga
1 hr
Thank you!
neutral DLyons : In this case my feeling is that the "sleep" refers to the toxin rather than the organism being drowsy. But it's hard to tell without more context!
3 hrs
Something went wrong...
4 KudoZ points awarded for this answer. Comment: "Thank you!"
53 mins

rest(ing) time

hope this is helpful, kind regards
Something went wrong...
4 hrs

dormant period

-
Peer comment(s):
neutral DLyons : Possible, but again I'd have expected but "período de latencia" if "dormant period" was meant.
1 hr
Something went wrong...
1 hr

latent period

Because metabolism of the parent compound is required for toxicity, the latent period reflects the time required for the toxic metabolites to accumulate

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Note added at 5 hrs (2011-03-03 17:52:03 GMT)
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Latent period it is not,

But it appears it may be "recovery time"

Prediction intervals, which take the covariation between parameters into account, were calculated for bioaccumulation factors, organism recovery time and simulations of internal concentrations as well as the time-course of survival under variable exposure. Organism recovery time was 28 days (95% prediction interval 25-31 days), indicating the possibility for carry-over toxicity from exposure events several weeks apart. The slow organism recovery and carry-over toxicity was caused by slow toxicodynamic recovery; toxicokinetic processes alone would have resulted in a recovery time of only 1-2 days

En general, las drogas depresoras del SNC reducen
el tiempo de latencia y/o aumentan la duración
del sueño (9). Para la realización de este ensayo, los
animales fueron inyectados por vía intraperitoneal
con 50 mg/kg de pentobarbital. Los extractos fueron
administrados 15 minutos antes de la inyección
de pentobarbital. Posteriormente, se determinó el
tiempo que cada animal tardaba en perder el reflejo
postural (tiempo de latencia) después de la administración
del pentobarbital y el tiempo transcurrido
desde que pierden el reflejo postural hasta que lo
"recuperan (tiempo de sueño)"


Sounds more like it
Peer comment(s):
neutral DLyons : This makes sense but "período de latencia" is so standard that I wonder why use "tiempo de sueño"?
2 hrs
You're right, I think Liz's answer is 100 %correct
Something went wrong...
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