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Freelance translator and/or interpreter, Verified site user
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Services
Translation
Expertise
Specializes in:
Medical (general)
Medical: Health Care
Medical: Pharmaceuticals
Rates
English to Chinese - Rates: 0.06 - 0.09 USD per word / 25 - 30 USD per hour
Source text - English Atrasentan was well tolerated following acute oral and intraperitoneal dosing in rodents, with adverse effects being limited to very high dose groups. Clinical signs included dyspnea, decreased activity, and prostration in both rats and mice and diarrhea in rats. Convulsions and cachexia were seen only with intraperitoneal administration in mice. Hematologic changes were noted in both the rat and dog repeat-dose studies. Increases in hematocrit, hemoglobin, red blood cell numbers and reticulocytes were observed in rats; there was a tendency for these same parameters to decrease in dogs. Elevations in erythropoietin were also noted in rats with high hematocrits. There was no evidence of bone marrow suppression, hemorrhage or red blood cell destruction in the dog toxicology studies.
Translation - Chinese 阿曲生坦在啮齿动物中急性经口给药和腹腔注射给药后耐受良好，不良作用仅限于极高剂量组。在大鼠和小鼠中均出现的临床体征包括呼吸困难、活动减少和虚弱，在大鼠中还出现腹泻。仅在腹腔注射给药的小鼠中观察到惊厥和萎靡不振。在大鼠和犬的重复给药研究中均观察到血液学变化。在大鼠中观察到血细胞比容、血红蛋白、红细胞数和网织红细胞升高；犬中的这些参数有降低趋势。在具有高血细胞比容的大鼠中还观察到红细胞生成素升高。犬毒理学研究中无骨髓抑制、出血或红细胞破坏的证据。
English to Chinese: Oncology
Source text - English PAPILLARY RENAL CELL CARCINOMA
The group of cancers that comprise the pRCC subtype includes pRCC type 1, pRCC type 2 and unclassified RCC with papillary architecture. These cancers are histologically,molecularly and clinically diverse.The recent publication of the TCGA pRCC study by the Cancer Genome Atlas Research Network highlighted this fact, and in their study they described several subgroups within both type 1 and type 2 tumors [5&&]. Alterations in several cancer-associated pathways were found across the spectrum of pRCC tumors, including alterations in the Hippo signaling pathway [mutationsin the NF2 (neurofibromin 2) gene], in the SWItch/Sucrose Non-Fermentable (SWI/SNF) complex [PBRM1 and SMARCB1 (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1)] and in several chromatin modifier pathways [SETD2, BAP1 and KDM6A (lysine (k)-specific demethylase 6A)].
Several subgroups in pRCC type 2 were linked with particularly poor clinical outcomes. Tumors with the CpG island methylator phenotype (CIMP) had increased DNA methylation compared with locithat were unmethylated in matched normal tissue from the same patient. At the molecular and metabolic level, many of these tumors have germline or somatic mutations in fumaratehydratase. Patients with germlinefumaratehydratasemutations can develop hereditary leiomyomatosis and RCC syndrome [42]. The CIMP phenotype is not unique to pRCC and is linked with a poor clinical prognosis in a variety of human malignancies [43].
English to Chinese: CMC - Chemistry, Manufacturing and Control
Source text - English IRIX HPLC method (IRIX-AP-712) is a specific and stability-indicating method used for the determination of purity and related substances of XXX. Related substances in XXX drug substance are reported as area percent. The area of an impurity is divided by the total area of all sample-related peaks from injection of a 0.3 mg/mL sample preparation. Related substances are reported by relative retention time (RRT) to the XXX parent peak and include impurities related to XXX such as synthetic byproducts and degradation products. The peak areas for all eluted compounds are summed and the purity of XXX is calculated as the percent of the total peak area.
The determination of residual solvents in XXX drug substance is based on the compendial method USP . Gas chromatography using J&W DB-624 capillary column with flame ionization detection (FID) is used to determine the amount of residual organic volatile impurities (residual solvents) per IRIX HS-GC method (IRIX-AP-59). The concentration of each solvent in the sample is determined using a standard curve generated from injection of standards with known solvent concentrations. Based on the observed signal, the solvent content of the sample is calculated as a function of the sample weight and dilution volume.
Translation - Chinese IRIX HPLC法（IRIX-AP-712）是一种用于测定XXX纯度和有关物质的专属和稳定性指示方的法。以面积百分比报告XXX原料药中的有关物质。进样0.3 mg/mL样品制备液，用杂质峰面积除以所有样品相关峰的总面积。通过XXX母峰的相对保留时间（RRT）报告有关物质，包括与XXX有关的杂质，如合成过程中产生的副产物和降解产物。将所有洗脱化合物的峰面积相加，XXX的纯度计算为总峰面积百分比。
XXX原料药中的残留溶剂应根据药典方法USP 测定。按照IRIX HS-GC方法（IRIX-AP-59），通过气相色谱法，使用J＆W DB-624毛细管柱及火焰离子化检测器（FID）测定残留的挥发性有机杂质（残留溶剂）的量。根据进样已知溶剂浓度的标准品生成的标准曲线测定样品中各溶剂的浓度。根据所观察到的信号，将样品的溶剂含量作为样品重量和稀释体积的函数进行计算。
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Translation education
Bachelor's degree - Harbin University of Science and Technology
Experience
Years of experience: 9. Registered at ProZ.com: Mar 2017.
Common
Technical Documents (CTD), Chemistry, Manufacturing and Control (CMC) dossiers,
pre-clinical safety profiles, nonclinical toxicology study reports, fertility
and embryo-fetal development study, PK data, PD data, treatment related
toxicity, safety summary, protocols and protocol amendments, sponsor audits.
Keywords: Translation, Chinese, Mandarin, English into Simplified Chinese, medical, pharmacology, toxicology, clinical trials, pharmaceuticals, life science. See more.Translation, Chinese, Mandarin, English into Simplified Chinese, medical, pharmacology, toxicology, clinical trials, pharmaceuticals, life science, China, Trados. See less.
