Apr 29, 2013 14:21
11 yrs ago
1 viewer *
Italian term

anche evidenza di impegno di circuiti frontosottocorticali

Italian to English Medical Medical (general) neurology
Dear all,

Here is the context in which the phrase appears:

Le implicazioni della deficienza di B12 nella disfunzione frontale con sintomi neuropsichiatrici è avvalorata dal fatto che la vitamina B12 somministrata a pazienti con vari tipi di disturbi da carenza (comprese sclerosi combinata, polineuropatia) si è dimostrata utile nel migliorare sintomi cognitivi e comportamentali in pazienti che avevano anche evidenza di impegno di circuiti frontosottocorticali (evidenziato anche con una batteria di test neuropsicologici comprendenti test per la valutazione della funzione frontale )

This is for a medical paper.

Many thanks,

Sophie

Proposed translations

+2
3 hrs
Selected

evidence of involvement of frontal-subcortical circuits

[patients who also had]
evidence of frontal-subcortical circuitry involvement

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181854/
[...] The major frontal-subcortical circuits include three behaviorally relevant circuits with origins in the prefrontal cortex: a dorsolateral prefrontal circuit, which mediates “executive” functions (ie, the organization of information to facilitate a response); an anterior cingulate circuit, which is involved in motivational mechanisms7-9 and an orbitofrontal circuit, which has lateral and medial divisions (Figure 1). The medial portion of the orbitofrontal circuit allows integration of visceral-amygdalar functions with the internal state of the organism, while the lateral portion is involved with integration of limbic and emotional information into contextually appropriate behavioral responses.
Peer comment(s):

agree Lirka : yes, http://www.ncbi.nlm.nih.gov/pubmed/8352676
2 hrs
thanks, lirka!
agree James (Jim) Davis : Wouldn't it be more appropriate to talk of "circuits firing"
19 hrs
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4 KudoZ points awarded for this answer. Comment: "Thanks very much for your quick answer. Sophie"
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