Glossary entry (derived from question below)
German term or phrase:
komplement-vermittelte toxizitaet
English translation:
complement dependent toxicity
Added to glossary by
Martina Kilgo
Sep 19, 2013 16:19
11 yrs ago
1 viewer *
German term
United States
If You Need Results
Native in: German 
, English
Works in: German to English, English to German
kompliment-vermittelte toxizitaet
German to English
Medical
Medical: Pharmaceuticals
Es geht hier um die mechanistische Wirkung von einem CD20 monoklonalen Antikoerper Medikament
Der Moderator moechte wissen wie die derzeit erhaeltlichen Medikamente CLL mechanistisch adressieren.
Der Befragte antwortet: Diese CD20 Antikoerper docken da an und werden durch verschiedene Mechanismen wirksam; es wird diskutiert, dass es ein direkter cytotoxischer Efffekt ist, oder eine antikoerper-abhaengige Cytotoxie, oder eine *kompliment-vermittelte* Toxizitaet.
Habt Ihr vielleicht Vorschlaege fuer mich?
Der Moderator moechte wissen wie die derzeit erhaeltlichen Medikamente CLL mechanistisch adressieren.
Der Befragte antwortet: Diese CD20 Antikoerper docken da an und werden durch verschiedene Mechanismen wirksam; es wird diskutiert, dass es ein direkter cytotoxischer Efffekt ist, oder eine antikoerper-abhaengige Cytotoxie, oder eine *kompliment-vermittelte* Toxizitaet.
Habt Ihr vielleicht Vorschlaege fuer mich?
Proposed translations
(English)
| 4 +4 | complement dependent toxicity |
uyuni
|
| 3 | complement-mediated toxicity |
Marga Shaw
|
Proposed translations
+4
7 mins
Selected
complement dependent toxicity
"Kompl*e*ment instead of Kompl*i*ment
http://de.wikipedia.org/wiki/Komplementsystem
http://en.wikipedia.org/wiki/Complement_system
Many examples:
https://www.google.de/#q="complement dependent toxicity"
http://de.wikipedia.org/wiki/Komplementsystem
http://en.wikipedia.org/wiki/Complement_system
Many examples:
https://www.google.de/#q="complement dependent toxicity"
Peer comment(s):
| agree |
Siegfried Armbruster
4 mins
|
|
Danke für das Kompliment, Siegfried ;-)
|
|
| agree |
Susanne Schiewe
: ;-)
8 mins
|
|
Danke schön, Susanne!
|
|
| agree |
Coqueiro
1 hr
|
|
Danke sehr, Coqueiro!
|
|
| agree |
Steffen Walter
14 hrs
|
| neutral |
Marga Shaw
: Please see my answer below
15 hrs
|
4 KudoZ points awarded for this answer.
Comment: "Thank you again uyuni :)"
14 hrs
Marga Shaw
United Kingdom
United Kingdom
Native in German
Specializes in field
United Kingdom
Language matters
Native in: German (Variants: Germany, Swiss, Austrian)
Works in: English to German, German to English
Related KudoZ points
:
154
complement-mediated toxicity
I would prefer here "complement-mediated toxicity", however, "complement" with an "e".
In agreement with these studies, exposure of human
umbilical vein endothelial cells to low concentration of anti-HLA class I antibodies induces expression of Bcl-2 and enhances the resistance to complement-mediated toxicity.
http://211.144.68.84:9998/91keshi/Public/File/25/25-/pdf/1-s...
Immunoglobulin purified from pools of antisera was also highly effective in producing cytotoxicity even in a complement-free system. This reaction proceeded more slowly, requiring nearly 48 hr to reach maximum effect in comparison to the 12 hr for complement-mediated toxicity.
http://cancerres.aacrjournals.org/content/37/3/696
The major activity of alemtuzumab and rituximab in the circulation is through complement-mediated toxicity.
http://www.newevidence.com/oncology/entries/In_vitro_evaluat...
Proposed hypotheses include a hypersensitivity/immune-mediated mechanism involving complement-mediated toxicity and mir-tazapine-induced antibodies against committed stem cells, proliferatingprecursors, or mature blood cells.
http://www.academia.edu/1615124/Accidental_Finding_of_Pancyt...
Although its mechanism of action has not been completely elucidated, several actions have been postulated, including complement-mediated toxicity.
http://www.medscape.com/viewarticle/766421_2
--------------------------------------------------
Note added at 15 hrs (2013-09-20 07:44:25 GMT)
--------------------------------------------------
Growing evidence suggests multiple interacting mechanisms, including complement-mediated cytotoxicity (CMC) and antibody-dependent cellular cytotoxicity (ADCC), play a role in the antitumor response of rituximab and other mAbs.
http://bloodjournal.hematologylibrary.org/content/111/3/1456...
--------------------------------------------------
Note added at 15 hrs (2013-09-20 08:13:21 GMT)
--------------------------------------------------
In previous work (... J. Exp. Med. 183, 2699–2704), we showed that multidrug resistance (MDR) cells created by continuous selection with the vinca alkaloid vincristine (HL60 RV+) or by retroviral infection (K562/human MDR 1 cells) exhibited significant resistance to complement-mediated cytotoxicity (CMC).
http://www.jbc.org/content/274/16/10877.long
"mediated" and "dependent" are different by definition, please see
http://www.thefreedictionary.com/mediated and http://www.thefreedictionary.com/dependent
In agreement with these studies, exposure of human
umbilical vein endothelial cells to low concentration of anti-HLA class I antibodies induces expression of Bcl-2 and enhances the resistance to complement-mediated toxicity.
http://211.144.68.84:9998/91keshi/Public/File/25/25-/pdf/1-s...
Immunoglobulin purified from pools of antisera was also highly effective in producing cytotoxicity even in a complement-free system. This reaction proceeded more slowly, requiring nearly 48 hr to reach maximum effect in comparison to the 12 hr for complement-mediated toxicity.
http://cancerres.aacrjournals.org/content/37/3/696
The major activity of alemtuzumab and rituximab in the circulation is through complement-mediated toxicity.
http://www.newevidence.com/oncology/entries/In_vitro_evaluat...
Proposed hypotheses include a hypersensitivity/immune-mediated mechanism involving complement-mediated toxicity and mir-tazapine-induced antibodies against committed stem cells, proliferatingprecursors, or mature blood cells.
http://www.academia.edu/1615124/Accidental_Finding_of_Pancyt...
Although its mechanism of action has not been completely elucidated, several actions have been postulated, including complement-mediated toxicity.
http://www.medscape.com/viewarticle/766421_2
--------------------------------------------------
Note added at 15 hrs (2013-09-20 07:44:25 GMT)
--------------------------------------------------
Growing evidence suggests multiple interacting mechanisms, including complement-mediated cytotoxicity (CMC) and antibody-dependent cellular cytotoxicity (ADCC), play a role in the antitumor response of rituximab and other mAbs.
http://bloodjournal.hematologylibrary.org/content/111/3/1456...
--------------------------------------------------
Note added at 15 hrs (2013-09-20 08:13:21 GMT)
--------------------------------------------------
In previous work (... J. Exp. Med. 183, 2699–2704), we showed that multidrug resistance (MDR) cells created by continuous selection with the vinca alkaloid vincristine (HL60 RV+) or by retroviral infection (K562/human MDR 1 cells) exhibited significant resistance to complement-mediated cytotoxicity (CMC).
http://www.jbc.org/content/274/16/10877.long
"mediated" and "dependent" are different by definition, please see
http://www.thefreedictionary.com/mediated and http://www.thefreedictionary.com/dependent
Discussion