Glossary entry (derived from question below)
German term or phrase:
Spindelformation
English translation:
spindle (cell) formation
Added to glossary by
David Hollywood
Jan 6, 2007 00:06
17 yrs ago
German term
Spindelformation
German to English
Medical
Medical (general)
Relating to formation of cells.
Proposed translations
(English)
3 +4 | spindel (cell) formation |
David Hollywood
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3 +4 | spindle formation |
Patricia Daehler
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Proposed translations
+4
6 mins
Selected
spindel (cell) formation
OSTERHOUT, W. J. V. Ueber Entstehung der karyokinetischen Spindel bei Equisetum. Jahrb. Wiss. Bot. 30: 159. 1902. --- Cell Studies 1. Spindle formation in ...
links.jstor.org/sici?sici=0006-8071(190308)36%3A2%3C81%3ASISF%3E2.0.CO%3B2-W - Similar pages
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Note added at 7 mins (2007-01-06 00:14:13 GMT)
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oops ... should read "spindle"
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Note added at 9 mins (2007-01-06 00:15:25 GMT)
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The question of whether a centrosome-independent pathway for spindle formation exists in vertebrate somatic cells, which always contain centrosomes, ...
linkinghub.elsevier.com/retrieve/pii/S0960982299002766 - Similar pages
links.jstor.org/sici?sici=0006-8071(190308)36%3A2%3C81%3ASISF%3E2.0.CO%3B2-W - Similar pages
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Note added at 7 mins (2007-01-06 00:14:13 GMT)
--------------------------------------------------
oops ... should read "spindle"
--------------------------------------------------
Note added at 9 mins (2007-01-06 00:15:25 GMT)
--------------------------------------------------
The question of whether a centrosome-independent pathway for spindle formation exists in vertebrate somatic cells, which always contain centrosomes, ...
linkinghub.elsevier.com/retrieve/pii/S0960982299002766 - Similar pages
4 KudoZ points awarded for this answer.
Comment: "Thank you very much in deed."
+4
7 mins
spindle formation
[PDF]
Foundations- Cell Division
File Format: PDF/Adobe Acrobat
Essential Cell Biology (Alberts) Ch 17. Histology and Cell Biology (Kierszbaum) ... Spindle formation (MT). Contractile ring (MF) ...
cellbiology.med.unsw.edu.au/units/pdf/FCellDivs4.pdf
The Anthelmintic Drug Mebendazole Induces Mitotic Arrest and ...
Abnormal spindle formation may be the key factor determining whether a cell undergoes apoptosis, whereas strong microtubule inhibitors elicit toxicity even ...
mct.aacrjournals.org/cgi/content/full/1/13/1201
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Note added at 10 mins (2007-01-06 00:16:41 GMT)
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Microtubules have a critical role in cell division, and consequently various microtubule inhibitors have been developed as anticancer drugs. In this study, we assess mebendazole (MZ), a microtubule-disrupting anthelmintic that exhibits a potent antitumor property both in vitro and in vivo. Treatment of lung cancer cell lines with MZ caused mitotic arrest, followed by apoptotic cell death with the feature of caspase activation and cytochrome c release. MZ induces abnormal *spindle formation* in mitotic cancer cells and enhances the depolymerization of tubulin, but the efficacy of depolymerization by MZ is lower than that by nocodazole. Oral administration of MZ in mice elicited a strong antitumor effect in a s.c. model and reduced lung colonies in experimentally induced lung metastasis without any toxicity when compared with paclitaxel-treated mice. We speculate that tumor cells may be defective in one mitotic checkpoint function and sensitive to the spindle inhibitor MZ. Abnormal *spindle formation* may be the key factor determining whether a cell undergoes apoptosis, whereas strong microtubule inhibitors elicit toxicity even in normal cells.
http://mct.aacrjournals.org/cgi/content/full/1/13/1201
http://cellbiology.med.unsw.edu.au/units/pdf/FCellDivs4.pdf
Foundations- Cell Division
File Format: PDF/Adobe Acrobat
Essential Cell Biology (Alberts) Ch 17. Histology and Cell Biology (Kierszbaum) ... Spindle formation (MT). Contractile ring (MF) ...
cellbiology.med.unsw.edu.au/units/pdf/FCellDivs4.pdf
The Anthelmintic Drug Mebendazole Induces Mitotic Arrest and ...
Abnormal spindle formation may be the key factor determining whether a cell undergoes apoptosis, whereas strong microtubule inhibitors elicit toxicity even ...
mct.aacrjournals.org/cgi/content/full/1/13/1201
--------------------------------------------------
Note added at 10 mins (2007-01-06 00:16:41 GMT)
--------------------------------------------------
Microtubules have a critical role in cell division, and consequently various microtubule inhibitors have been developed as anticancer drugs. In this study, we assess mebendazole (MZ), a microtubule-disrupting anthelmintic that exhibits a potent antitumor property both in vitro and in vivo. Treatment of lung cancer cell lines with MZ caused mitotic arrest, followed by apoptotic cell death with the feature of caspase activation and cytochrome c release. MZ induces abnormal *spindle formation* in mitotic cancer cells and enhances the depolymerization of tubulin, but the efficacy of depolymerization by MZ is lower than that by nocodazole. Oral administration of MZ in mice elicited a strong antitumor effect in a s.c. model and reduced lung colonies in experimentally induced lung metastasis without any toxicity when compared with paclitaxel-treated mice. We speculate that tumor cells may be defective in one mitotic checkpoint function and sensitive to the spindle inhibitor MZ. Abnormal *spindle formation* may be the key factor determining whether a cell undergoes apoptosis, whereas strong microtubule inhibitors elicit toxicity even in normal cells.
http://mct.aacrjournals.org/cgi/content/full/1/13/1201
http://cellbiology.med.unsw.edu.au/units/pdf/FCellDivs4.pdf
Peer comment(s):
agree |
David Hollywood
: you got it right first time and get my vote :)
2 mins
|
Thank you!
|
|
agree |
John Speese
: Mine too.
15 hrs
|
Thank you John!
|
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agree |
Julia Esrom
17 hrs
|
Thank you Julia!
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agree |
Dr.G.MD (X)
3 days 16 hrs
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Thank you Gerhard!
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