Glossary entry (derived from question below)
French term or phrase:
versant plutôt Th1/Th2
English translation:
tending more towards Th1
Added to glossary by
roseh (X)
Jan 1, 2008 22:17
16 yrs ago
2 viewers *
French term
versant plutôt Th1/Th2
French to English
Medical
Medical (general)
traitement de bronchopneumopathie
Sur un modèle de rat présentant une hyperplasie des cellules à mucus induite par une inhalation unique de lipopolysaccharide (**versant plutôt Th1**) ou d’ovalbumine (**versant plutôt Th2**), le traitement oral quotidien par roflumilast permettait de réduire significativement cette hyperplasie des cellules à mucus, et donc, possiblement présenterait un intérêt dans le traitement des bronchopneumopathie chronique obstructive et des asthmes.
I'm not sure what part of speech "versant" is here - is it a noun (meaning slope or incline) or a form of the verb meaning to pour? Do Th1 and Th2 refer to types of T helper cells?
Does anyone have any idea how to translate this phrase? Thanks, and Happy New Year to all!
I'm not sure what part of speech "versant" is here - is it a noun (meaning slope or incline) or a form of the verb meaning to pour? Do Th1 and Th2 refer to types of T helper cells?
Does anyone have any idea how to translate this phrase? Thanks, and Happy New Year to all!
Proposed translations
(English)
3 | tending more towards Th1 | Kate Hudson (X) |
4 +2 | (rather) leaning towards Th1/Th2 | Isabelle Berquin |
4 | Th1 or Th2 phenotype cytokine profile hyperplasia | Drmanu49 |
Proposed translations
1 hr
Selected
tending more towards Th1
I think this might fit the context
4 KudoZ points awarded for this answer.
11 mins
Th1 or Th2 phenotype cytokine profile hyperplasia
Les cellules T du donneur produisent des cytokines TH1, pourtant il a été démontré ... Le versant bénéfique de cette réponse immune est constitué par cette ...
linkinghub.elsevier.com/retrieve/pii/S036981140600006X
The clinical characteristics associated with this disease result from overproduction of Th1 cytokines including interferon-gamma (IFN-gamma), interleukin-2 ...
www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&uid=9166851&cmd...
Citrobacter rodentium Infection in Mice Elicits a Mucosal Th1 Cytokine Response ... doubles in thickness and there is massive epithelial cell hyperplasia. ...
iai.asm.org/cgi/content/abstract/67/6/3031 -
Aspergillus antigen induces robust Th2 cytokine production, inflammation, ... by type 2 T-helper cell (Th2) inflammation, goblet cell hyperplasia, ...
repositories.cdlib.org/postprints/69/ - 17k -
Murine colonic hyperplasia is a naturally occurring disease of ..... Infiltrating T cells are of a Th1 phenotype. The cytokine profile in the distal colons ...
www.pubmedcentral.nih.gov/articlerender.fcgi?artid=96617
Gastric Helicobacter Infection Induces a Th2 Phenotype but Does Not Elevate ... The mice were scored for severity of gastric inflammation, hyperplasia, ...
iai.asm.org/cgi/content/full/73/3/1664
The percentages intimal hyperplasia (severity of TA) that had developed after aortic ... Like BN rats, F344 rats show a Th2 type cytokine profile, ...
linkinghub.elsevier.com/retrieve/pii/S0041134500020315 -
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Note added at 13 mins (2008-01-01 22:31:19 GMT)
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with a predominant Th1 or Th2 phenotype cytokine profile
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Note added at 15 mins (2008-01-01 22:32:55 GMT)
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with a predominant Th1 phenotype cytokine profile hyperplasia
or with a predominant Th2 phenotype cytokine profile hyperplasia
linkinghub.elsevier.com/retrieve/pii/S036981140600006X
The clinical characteristics associated with this disease result from overproduction of Th1 cytokines including interferon-gamma (IFN-gamma), interleukin-2 ...
www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&uid=9166851&cmd...
Citrobacter rodentium Infection in Mice Elicits a Mucosal Th1 Cytokine Response ... doubles in thickness and there is massive epithelial cell hyperplasia. ...
iai.asm.org/cgi/content/abstract/67/6/3031 -
Aspergillus antigen induces robust Th2 cytokine production, inflammation, ... by type 2 T-helper cell (Th2) inflammation, goblet cell hyperplasia, ...
repositories.cdlib.org/postprints/69/ - 17k -
Murine colonic hyperplasia is a naturally occurring disease of ..... Infiltrating T cells are of a Th1 phenotype. The cytokine profile in the distal colons ...
www.pubmedcentral.nih.gov/articlerender.fcgi?artid=96617
Gastric Helicobacter Infection Induces a Th2 Phenotype but Does Not Elevate ... The mice were scored for severity of gastric inflammation, hyperplasia, ...
iai.asm.org/cgi/content/full/73/3/1664
The percentages intimal hyperplasia (severity of TA) that had developed after aortic ... Like BN rats, F344 rats show a Th2 type cytokine profile, ...
linkinghub.elsevier.com/retrieve/pii/S0041134500020315 -
--------------------------------------------------
Note added at 13 mins (2008-01-01 22:31:19 GMT)
--------------------------------------------------
with a predominant Th1 or Th2 phenotype cytokine profile
--------------------------------------------------
Note added at 15 mins (2008-01-01 22:32:55 GMT)
--------------------------------------------------
with a predominant Th1 phenotype cytokine profile hyperplasia
or with a predominant Th2 phenotype cytokine profile hyperplasia
+2
11 mins
(rather) leaning towards Th1/Th2
I understand this as "leaning towards th1 or Th2 type T helper cells", or in other words with primary activation/hyperplasia of Th1 or Th2 cells, respectively.
For a discussion of the Th1/Th2 Model for helper T cells, see http://en.wikipedia.org/wiki/Th1
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Note added at 22 mins (2008-01-01 22:40:16 GMT)
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The exposure to high-level LPS with antigens resulted in increased antigen-specific Th1 responses, whereas a low dose of LPS resulted in Th2 sensitization. http://www.pnas.org/cgi/content/full/103/7/2286
The reference above suggests that both the antigen used (LPS vs ovalbumin) and its amount can lead to a respones that is primarily a Th1 or a Th2 response.
For a discussion of the Th1/Th2 Model for helper T cells, see http://en.wikipedia.org/wiki/Th1
--------------------------------------------------
Note added at 22 mins (2008-01-01 22:40:16 GMT)
--------------------------------------------------
The exposure to high-level LPS with antigens resulted in increased antigen-specific Th1 responses, whereas a low dose of LPS resulted in Th2 sensitization. http://www.pnas.org/cgi/content/full/103/7/2286
The reference above suggests that both the antigen used (LPS vs ovalbumin) and its amount can lead to a respones that is primarily a Th1 or a Th2 response.
Peer comment(s):
agree |
Michael Barnett
: Yes, leaning toward, or tilting to a primarily Th1 response.
5 hrs
|
agree |
liz askew
13 hrs
|
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