Glossary entry (derived from question below)
English term or phrase:
tampered dosage form
English answer:
dosage form has been manipulated by mechanical, thermal, and/or chemical means
Added to glossary by
Oso (X)
Sep 16, 2005 06:28
19 yrs ago
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English term
tampered
English
Medical
Medical: Pharmaceuticals
administration of a tampered dosage form to a patient population
Change log
Sep 16, 2005 16:26: Oso (X) changed "Field" from "Law/Patents" to "Medical"
Responses
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dosage form has been manipulated (more info. below)
"...The term "tampered dosage form" is defined for purposes of the present invention to mean that *****the dosage form has been manipulated by mechanical, thermal, and/or chemical means which changes the physical properties of the dosage***** for, e.g., to liberate the opioid agonist forimmediate release if it is in sustained release form, or to make the opioid agonist available for inappropriate use such as administration by an alternate route, e.g., parenterally. The tampering can be, e.g., by means of crushing, shearing, grinding, chewing, dissolution in a solvent, heating, (e.g., greater than about 45.degree. C.), or any combination thereof. ..."
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http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=...
Good luck from Oso ¶:^)
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6 mins
when the dosage is tampered, such as by crushing a tablet
when the dosage is tampered, it is changed, for example when crushed for ease in swallowing.
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