May 28, 2014 00:08
10 yrs ago
English term

paranodes

English Medical Medical (general) proteíns
In rat Schwann cells NF2 protein was found to co-localise with Rho at paranodes
Change log

May 28, 2014 02:04: Jessica Noyes changed "Term asked" from "PARANODES" to "paranodes"

Responses

6 hrs

part of nerve fiber

Paranodes are adjacent to the nodes of Ranvier. Here the spiraled lamellae of myelin gradually terminate.
http://www.bu.edu/agingbrain/chapter-3-normal-myelinated-ner...

See illustration here:
http://vanat.cvm.umn.edu/neurHistAtls/pages/images/Glia15.gi...
Something went wrong...
12 hrs

Please see below


The term "paranode" is used in neuroscience to define a very specific type of cellular structure that, while not part of the neuron itself, plays an important role in excitatory signal transduction.

http://neuromuscular.wustl.edu/lab/schcell.html#ranvier
In the above link you find a couple of illustrations of a paranode.

The term paranode refers to the cytoplasmic region of the myelin internode that is adjacent to the node.
http://vanat.cvm.umn.edu/neurHistAtls/pages/glia15.html

Myelination organizes axons into distinct domains that allow nerve impulses to propagate in a saltatory manner. The edges of the myelin sheath are sealed at the paranodes by axon–glial junctions that have a crucial role in organizing the axonal cytoskeleton. Here we propose a model in which the myelinated axons depend on the axon–glial junctions to stabilize the cytoskeletal transition at the paranodes. Thus paranodal regions are likely to be particularly susceptible to damage induced by demyelinating diseases such as multiple sclerosis.
http://journals.cambridge.org/action/displayAbstract;jsessio...
Something went wrong...

Reference comments

1 hr
Reference:

Here you have a description and an image of paranodes

Something went wrong...
Term search
  • All of ProZ.com
  • Term search
  • Jobs
  • Forums
  • Multiple search