Jul 21, 2014 06:38
10 yrs ago
7 viewers *
English term

chemokine receptor ligand (C-X-C motif) ligand 3

English Law/Patents Biology (-tech,-chem,micro-) cytogenetics
Is there a difference between the 2 follwoing terms:
1- chemokine (C-X-C motif) ligand 3
2- chemokine receptor ligand (C-X-C motif) ligand 3

For first term, text reads:
*** Cells have increased expression of interleukin-8; reticulon 1; and chemokine (C-X-C motif) ligand 3, relative to that of a human cell which is a fibroblast, a mesenchymal stem cell, or an iliac crest bone marrow cell.

I simply translated it as CXCL3 Gene (protein-coding) or CXCL3 cytokine (a type of cytokines)

For second term, text says:
*** Cells have increased expression of interleukin-8; reticulon 1; and chemokine receptor ligand (C-X-C motif) ligand 3, relative to that of a human cell which is a fibroblast, a mesenchymal stem cell, or an iliac crest bone marrow cell.

It is little confusing. Can I translate it in the same way of FIRST term or they are different?
I think, the second term an be translated as "the ligand of the receptor of CXCL3 gene.
Please advise if this is a proper translation!

Thank you in advance.
FS

Responses

2 hrs
Selected

Yes, there is a difference

There are at least 46 chemokine ligands in humans. There are also 18 functionally signaling chemokine receptors (plus one, CXCR7, which has been recently reported as a potential chemokine receptor) and two 'decoy' or 'scavenger' receptors, DARC and D6, which are known to bind several chemokines but do not signal; their function may be to modulate inflammatory responses through their ability to remove chemokine ligands from inflammatory sites.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1794421/

Note from asker:
Good link! Thank you
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