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Note added at 3 hrs (2009-03-30 02:35:15 GMT)
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"line" может здесь подразумевать то же самое "line", что и в словосочетаниях "first-line therapy" и "second-line therapy"...

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Note added at 3 hrs (2009-03-30 02:38:22 GMT)
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Table 1. Patient and disease characteristics
...
**Prior chemotherapy lines*
Median number/patients (range): 3(1-6)
...
http://annonc.oxfordjournals.org/cgi/reprint/7/10/1065

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Note added at 3 hrs (2009-03-30 02:39:50 GMT)
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Критерии для подгрупп включали группу рандомизации, время после завершения последней химиотерапии, **число предшествовавших линий химиотерапии**, проводившееся ранее лечение таксанами, препарат платины, запланированный для лечения, возраст и функциональный статус.
http://medi.ru/doc/0446059.htm

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Note added at 4 hrs (2009-03-30 02:42:48 GMT)
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...tamoxifen generally is used as **first-line therapy in this setting**...
http://www3.interscience.wiley.com/cgi-bin/fulltext/75504663...

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Note added at 4 hrs (2009-03-30 02:44:27 GMT)
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Patients were pre-treated with a median of **two (range 1-4) conventional chemotherapy lines before** high-dose cyclophosphamide ...
http://www.haematologica.org/cgi/reprint/86/7/706

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Note added at 4 hrs (2009-03-30 02:45:58 GMT)
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...previous chemotherapy lines 1: 12 pts (34%), 2: 10 pts (28%), greater than or equal to3: 10 pts (28%).
http://www.nature.com/bjc/journal/v89/n10/full/6601382a.html

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Note added at 4 hrs (2009-03-30 02:47:02 GMT)
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...three or more previous chemotherapy lines...
http://annonc.oxfordjournals.org/cgi/content/full/15/8/1222

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Note added at 4 hrs (2009-03-30 02:48:04 GMT)
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Patients with recurrent ovarian carcinoma, 6 months after treatment with a platinum-based regimen and with **no more than two previous chemotherapy lines**, were randomized to receive carboplatin...
http://annonc.oxfordjournals.org/cgi/content/full/16/5/749

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Note added at 4 hrs (2009-03-30 02:50:40 GMT)
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In the last decade the treatment of advanced-metastatic non-small cell lung cancer has substantially improved. If in the early 90s there was still concern about the real efficacy of chemotherapy over best suppotive care
alone in the advanced setting, constant developments in clinical research have demonstrated the survival advantage of active anti-cancer drugs **not only in the first-line setting, but, lately, even in patients with recurrent disease after failure of two previous chemotherapy lines**. ...
http://annonc.oxfordjournals.org/cgi/reprint/17/suppl_2/ii36

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Note added at 4 hrs (2009-03-30 02:52:19 GMT)
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The median time elapsed between the beginning of the **first chemotherapy line** for metastatic disease and chronoIFLO onset was 24 months...
http://theoncologist.alphamedpress.org/cgi/content/full/11/1...

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Note added at 4 hrs (2009-03-30 02:55:01 GMT)
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**** METASTATIC SETTING:

IN THE ADJUVANT SETTING, AS OPPOSED TO THE METASTATIC SETTING, PATIENTS DO NOT HAVE ROOTED TUMORS. HOWEVER, THEY MIGHT HAVE TUMORS CIRCULATING IN THEIR BLOOD STREAM...
http://www.colorectal-cancer.ca/en/news-and-resources/genent...