English to Romanian Medical Medical: Pharmaceuticals

Let P1 be the proportion for XXX and P2 be the proportion for YYY.
Equivalently, if the lower bound of the two-sided 95% confidence interval for P1 P2 is greater than -0.100 based on the Z test with unpooled variance estimate, non-inferiority will be concluded.

Using Farrington and Manning’s method for non-inferiority testing with a 1 sided alpha of 0.025, assuming a 75% early clinical response rate in each group and a 10% non-inferiority bound delta, a sample size of 100 patients per group is required for 70% power.