This question was closed without grading. Reason: Answer found elsewhere
Oct 8, 2020 10:36
4 yrs ago
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English term
thermo explorer
English to French
Science
Chemistry; Chem Sci/Eng
In a patent: chemistry, chromatography
Step 1. Halide monomers (300 mmol) were dissolved anhydrous DMF (10 ml/mmol, 3 ml) under argon atmosphere.
NaH (60% suspension in mineral oil, 2 equiv, 600 mmol, 30 mg) was added at 0 °C to each reaction vial. Each
reaction vial was stirred at 0 °C for 30 min. SEM chloride (2 equiv, 600 mmol, 106 mL) was added dropwise to the reaction
mixture and stirring was continued at 25 °C for 16 hrs. Completion of reaction was monitored by LCMS/TLC and solvents
were stripped off using thermo explorer (1 hr, 5 torr, (0.66 kPa) and 45 °C). The residue was purified by column chromatography
using 5-10% ethyl acetate-hexane as eluent. For each monomer yield was around 75-80%.
The reaction was checked by LCMS. The reaction mixture was filtered and the solvent was evaporated
in thermo explorer (1 hr, 5 torr, and 45°C)
NaH (60% suspension in mineral oil, 2 equiv, 600 mmol, 30 mg) was added at 0 °C to each reaction vial. Each
reaction vial was stirred at 0 °C for 30 min. SEM chloride (2 equiv, 600 mmol, 106 mL) was added dropwise to the reaction
mixture and stirring was continued at 25 °C for 16 hrs. Completion of reaction was monitored by LCMS/TLC and solvents
were stripped off using thermo explorer (1 hr, 5 torr, (0.66 kPa) and 45 °C). The residue was purified by column chromatography
using 5-10% ethyl acetate-hexane as eluent. For each monomer yield was around 75-80%.
The reaction was checked by LCMS. The reaction mixture was filtered and the solvent was evaporated
in thermo explorer (1 hr, 5 torr, and 45°C)
Change log
Oct 8, 2020 11:04: Tony M changed "Field" from "Law/Patents" to "Science" , "Field (write-in)" from "chemistry, chromatography" to "In a patent: chemistry, chromatography"
Discussion
See https://assets.thermofisher.com/TFS-Assets/LPD/Product-Infor... which refers to the "Introduction of the Discovery and Discovery MKII systems, along with the Explorer systems"
Also, https://www.americaninstrument.com/pdf/1337D-CENTRI.pdf where it describes different models of their Explorer SpeedVac Concentrator.