This site uses cookies. Some of these cookies are essential to the operation of the site, while others help to improve your experience by providing insights into how the site is being used. For more information, please see the ProZ.com privacy policy.
Cookie settings
knopatheromatose
Belgische artsenkorps

Glossary entry

Dutch term or phrase:

canaliculaire leverset

English translation:

elevated GGT and ALP/cholestatic liver tests

Added to glossary by Barend van Zadelhoff
Apr 23, 2012 18:36
12 yrs ago
12 viewers *
Dutch term

canaliculaire leverset

Dutch to English Medical Medical (general)
A clinical finding of an elderly patient: Gestoorde canaliculaire leverset met onderliggende [levercirrose, etc.] als belangrijke factor en eveneens onderliggende cardiale stuwingsproblematiek.
Proposed translations (English)
2 +1 canalicular liver tests
3 canalicular liver function
References
Gestoorde - Dutch - English Translation...
Change log

Jun 4, 2012 02:08: Barend van Zadelhoff Created KOG entry

Jun 4, 2012 02:08: Barend van Zadelhoff changed "Edited KOG entry" from "<a href="/profile/133080">Barend van Zadelhoff's</a> old entry - "canaliculaire leverset"" to ""Elevated GGT and ALP/cholestatic liver tests""

Discussion

SJLD Apr 24, 2012:
Yes, that would work too I should think. Elevated cholestatic LFTs.

Liver Cirrhosis: New Research - Résultats Google Recherche de Livres
books.google.lu/books?isbn=1594541809...T. M. Chen - 2005 - Medical - 227 pages
Recently, some investigators also observed that the elevation of cholestatic liver function tests (alkaline phosphatase, gamma-glutamyltransferase and bilirubin)
Josephine Isaacs (X) Apr 24, 2012:
cholestatic liver tests Perhaps 'cholestatic liver tests' can be used? This is certainly a commonly used term in hepatology.
Barend van Zadelhoff Apr 23, 2012:
yes, this was my line of thought as well

"LFTs suggestive of bile obstruction or cholestasis" would be a free translation :-) of 'abnormal GGT and ALP levels' and perhaps a little bit more safe/general option because we are not 100% sure it is just these two enzyms
SJLD Apr 23, 2012:
Raised GGT and ALP are indicators of cholestasis, so that would certainly make sense of the "canaliculaire" connection - something wrong with the biliary tree. Perhaps we could say LFTs suggestive of bile obstruction or cholestasis?

http://www.britishlivertrust.org.uk/home/the-liver/liver-dis...
Alkaline phosphatase (ALP), an enzyme found mainly in the bile ducts of the liver. Increases in ALP and another liver enzyme called Gamma GT (GGT) can indicate obstructive or cholestatic liver disease, where bile is not properly transported from the liver because of obstruction (blockage) of the bile duct.
Barend van Zadelhoff Apr 23, 2012:
yes, that was my problem
it hardly occurs anywhere
what do you think of abnormal GGT and ALP levels?
I could get no definite proof it concerned just these two enzymes though, but it seems plausible
SJLD Apr 23, 2012:
liver function tests - I'd drop the "canalicular" - never ever seen it in English to qualify LFTs. It won't mean anything to an English-speaking MD.

Proposed translations

+1
1 hr
Selected

canalicular liver tests

seems to be typically Belgian

or: abnormal GGT and ALP levels

'leverset' means 'liver tests'

Leverset (AF, GGT, AST, ALT, Bili)

http://www.kuleuven.be/anesthesie/co_assistenten/Vandermeule...

'canalicular' refers to the 'bile canaliculi'

http://en.wikipedia.org/wiki/Bile_canaliculus

Cholestatische en canaliculaire levertesten
- γGT : (♀<40) (♂<50) (nier, lever (brush-border),
pancreas, hart). Vooral verhoogd bij
galwegobstructie, maar ook medicatie en alcohol
(enzyminductie), myocardinfarct, congestief
hartfalen, acute pancreatitis, chronisch nierfalen,
COPD)
- Alkalische fosfatase (40-120) (4 fracties : darm,
lever, bot, placenta). Meestal significant gestegen
bij cholestatisch leverlijden, vaak enige afwijking
(met hoge γGT) bij galstuwing, multifocale
intrahepatische galwegobstructie, of bij infiltratieve
ziekten (sarcoïdose, amyloïdose, HCC, diffuse
metastasering).

http://www.internisten-rijnland.nl/Documenten/LEVERFUNCTIES2...

apparently the canalicular liver tests refer to gamma-GT and AF


Elevated serum GGT activity can be found in diseases of the liver, biliary system, and pancreas. In this respect, it is similar to alkaline phosphatase (ALP) in detecting disease of the biliary tract.

http://en.wikipedia.org/wiki/Gamma-glutamyl_transpeptidase


Both liver transaminases and canalicular liver tests were normal.

http://www.wjgnet.com/1007-9327/full/v16/i23/2959.htm



--------------------------------------------------
Note added at 41 days (2012-06-04 02:11:57 GMT) Post-grading
--------------------------------------------------

Thank you, Cynthia.
Peer comment(s):
agree Vert-ical Tr (X)
12 hrs
Thank you, Vert-ical Tr! I prefer my second option '(abnormal) GGT and ALP levels', and its 'translations' suggested in the discussion entries can be used as well.
Something went wrong...
4 KudoZ points awarded for this answer.
41 mins

canalicular liver function

I think that 'set' refers to the functioning of the canaliculi.
Something went wrong...

Reference comments

31 mins
Reference:

Gestoorde - Dutch - English Translation and Examples
mymemory.translated.net/t/Dutch/English/gestoorde
Gestoorde leverfunctie, Impaired hepatic function, English, Dutch, Translation, human translation, automatic translation.
Terminologie financieel management - Google Books Result
books.google.co.uk/books?isbn=9031220280...F. van Amerongen - 2001 - 403 pages
... to house, to offer shelter onderliggend underlying onderliggende positie underlying ... undertaker ondernemer (werkgever) employer ondernemer belast met ...
•
www.ncbi.nlm.nih.gov/pubmed/12350135
by S Yu - 2002 - Related articles
... investigated in jaundiced rats with elevated plasma concentrations of conjugated bilirubin as a result of impaired canicular transport of bilirubin glucuronides.
• Impaired localisation and transport function of canalicular Bsep in ...
ukpmc.ac.uk/articles/PMC1773741
by FA Crocenzi - 2003 - Cited by 44 - Related articles
AIMS: To evaluate which step/s of the hepatocellular bile salt transport are impaired by taurolithocholate, focusing on changes in localisation of the canalicular ...
• Impaired localisation and transport function of canalicular Bsep in ...
connection.ebscohost.com/.../impaired-localisation-transport-function...
EBSCOhost serves thousands of libraries with premium essays, articles and other content including Impaired localisation and transport function of canalicular ...



--------------------------------------------------
Note added at 33 mins (2012-04-23 19:09:20 GMT)
--------------------------------------------------

leverset =
liver panel/liver tests/liver function tests??

Good luck!

--------------------------------------------------
Note added at 35 mins (2012-04-23 19:11:17 GMT)
--------------------------------------------------

www.sciencedirect.com/science/article/pii/S0168827809007405
by JM Stapelbroek - 2010 - Cited by 24 - Related articles
21 Nov 2009 – Canalicular transport defects in liver disease ..... This marginal effect contrasts with the results obtained in patients with BRIC. After starting ...

--------------------------------------------------
Note added at 36 mins (2012-04-23 19:12:15 GMT)
--------------------------------------------------

www.ncbi.nlm.nih.gov/pubmed/12763363
by G Zollner - 2003 - Cited by 163 - Related articles
BACKGROUND/AIMS: Information about alterations of hepatobiliary transporter expression in primary biliary cirrhosis (PBC) could provide important insights ...
Something went wrong...
Close search
Term search
  • All of ProZ.com
  • Term search
  • Jobs
  • Forums
  • Multiple search