Glossary entry

Chinese term or phrase:

低浓度高活性

English translation:

high specific activity even at/when it is used at low(er) concentrations

Added to glossary by DKDL
Feb 18, 2016 01:44
8 yrs ago
Chinese term

低浓度高活性

Chinese to English Science Chemistry; Chem Sci/Eng
研究发现在壬二酸中引进甘氨酸后,其衍生物壬二酰二甘氨酸钾具有很高的水溶性、低浓度高活性、极低毒性以及极好的化学稳定性,从而使壬二酸能够更广泛的应用于化妆品中。

As it appears, the phrase "低浓度高活性" doesn't really make sense. My guess is that it means "high activity even at low concentrations". The difficulty lies in how to concisely and accurately express that meaning. Any help would be greatly appreciated.

Proposed translations

24 mins
Selected

high specific activity even at/when it is used at low(er) concentrations

[PDF]Azeloyl-Glycine: a new active in skin disequilibrium
www.iscd.it/.../AZELOYL-GLYCINE---A-NEW-ACTIVE-IN-SKIN-DIS....
by L Rigano - ‎2003 - ‎Cited by 6 - ‎Related articles
Key words: Sebum contro/; Skin lighteners; Azelaic acid; ... However, its limits in topica! formulations are well known, even when it is used at lower ... exhibits very high water solubility, high specific activity at low concentration, low toxicity and ...

Alernative to azelaic acid - Over-the-counter acne medications and ...
www.acne.org › ... › Over-the-counter acne medications and products
Sep 17, 2009 - Azeloyl Glycine is a new type azelaic acid derivative that is claimed to be superior ... The dermatological uses of Azelaic acid are related to its anti-sebhorreic, anti-mycotic and anti-acne properties. However, its limits in topical formulations are well known, even when it is used at lower concentrations than the pharmacological ones. Firstly, a high percentage amount is required to be effective. Secondly, being insoluble at high concentrations, it provides poor cosmetic properties to the formulations, which result to be thick and difficult to spread over the skin. Finally, its solubilisation by adequate chemical methods (e.g. neutralisation) brings to loss of Azelaic acid content during shelf life, as it decarboxylates. In order to overcome these problems a new molecule, Potassium Azeloyl di-Glycinate, has been produced. It exhibits very high water solubility, high specific activity at low concentration, low toxicity and adequate chemical stability and compatibility. Serial cosmetic efficacy essays have been carried out with informed volunteers. The preliminary results are very interesting. It proved very effective as skin whitening agent and sebum normalizer. In addition, other skin parameters like moisturization and some elastic properties show remarkable improvements.


High activity even at low concentrations
Study found that after the introduction of azelaic acid glycine... has a high water solubility, lhigh specific activity at low concentration, low toxicity and excellent chemical stability, making azelaic acid can be more widely used in the field of cosmetics industry.

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Note added at 25 mins (2016-02-18 02:10:39 GMT)
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I see you still fighting with your acne-related files. I would love to see the results if it is possible. I am very interested.

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Note added at 26 mins (2016-02-18 02:11:09 GMT)
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http://www.acne.org/messageboard/topic/248515-alernative-to-...

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Note added at 28 mins (2016-02-18 02:12:43 GMT)
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Garden of Wisdom - Delphi Forums Mobile
m.delphiforums.com/gardenofwisdom/messages/3424/11
Whole combo as in mandelic acid + white daisy + lite N brite? ... even when used at lower concentrations than the pharmacological ones. ... It exhibits very high water solubility, amphyphily, high specific activity at low concentration, low toxicity and adequate ... Azeloyl Glycine is same as Azelaic acid right?

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Note added at 5 days (2016-02-23 04:29:55 GMT) Post-grading
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My pleasure :) 謝謝
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4 KudoZ points awarded for this answer. Comment: "Thank you for your great answer!"
+1
23 mins

high activity coefficient at low concentrations

See examples from Wikipedia:

1. "An activity coefficient is a factor used in thermodynamics to account for deviations from ideal behaviour in a mixture of chemical substances......Deviations from ideality are accommodated by modifying the concentration by an activity coefficient"

2. "Specific ion Interaction Theory (SIT theory) is a theory used to estimate single-ion activity coefficients in electrolyte solutions at relatively high concentrations"
Peer comment(s):

agree ysun : I think "high activity even at low concentrations" would be better.
3 days 14 hrs
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