Glossary entry (derived from question below)
English term or phrase:
disposition (in this context)
English answer:
distribution, metabolism and excretion
Added to glossary by
GEKAMON (X)
Jan 31, 2008 15:42
16 yrs ago
22 viewers *
English term
GEKAMON (X)
disposition (in this context)
English
Medical
Medical: Health Care
Use of concomitant medications that may affect renal function or metformin disposition: Concomitant medication(s) that may affect renal function or result in significant hemodynamic change or may interfere with the disposition of this drug, such as cationic drugs that are eliminated by renal tubular secretion, should be used with caution.
Dear colleagues! Help me please to make it out whether "disposition" in this context means biotransformation or excretion (elimination). Thanks in advance!
Dear colleagues! Help me please to make it out whether "disposition" in this context means biotransformation or excretion (elimination). Thanks in advance!
Responses
| 3 +3 | distribution, metabolism and excretion |
Helen Genevier
|
| 4 -1 | excreation |
Veronica Prpic Uhing
|
Responses
+3
38 mins
Selected
distribution, metabolism and excretion
I found a couple of definitions in glossaries:
"Drug disposition: Drug disposition refers to all processes involved in the absorption, distribution metabolism and excretion of drugs in a living organism" http://www.chem.qmul.ac.uk/iupac/medchem/ah.html#d9
Disposition: The disposition of a drug refers to the fate of the drug once it has been absorbed. The processes that occur following absorption are distribution and elimination. Thus, disposition of an intramuscularly administered drug following absorption into the circulatory system, will be distribution to its site of action followed by elimination of the drug by biotransformation or excretion.
http://facpub.stjohns.edu/~yoburnb/pages/dropdowncurrent.htm...
--------------------------------------------------
Note added at 1 hr (2008-01-31 16:44:31 GMT)
--------------------------------------------------
Note to GEKAMON: Here's a difference "Drug disposition includes the phenomena of absorption, distribution, and elimination. Pharmacokinetics is the study of time course of these processes and
the time course of pharmacological effects."
http://depts.washington.edu/pha/students/handbook/2007/i.pdf
"Drug disposition: Drug disposition refers to all processes involved in the absorption, distribution metabolism and excretion of drugs in a living organism" http://www.chem.qmul.ac.uk/iupac/medchem/ah.html#d9
Disposition: The disposition of a drug refers to the fate of the drug once it has been absorbed. The processes that occur following absorption are distribution and elimination. Thus, disposition of an intramuscularly administered drug following absorption into the circulatory system, will be distribution to its site of action followed by elimination of the drug by biotransformation or excretion.
http://facpub.stjohns.edu/~yoburnb/pages/dropdowncurrent.htm...
--------------------------------------------------
Note added at 1 hr (2008-01-31 16:44:31 GMT)
--------------------------------------------------
Note to GEKAMON: Here's a difference "Drug disposition includes the phenomena of absorption, distribution, and elimination. Pharmacokinetics is the study of time course of these processes and
the time course of pharmacological effects."
http://depts.washington.edu/pha/students/handbook/2007/i.pdf
Note from asker:
| So it means drug pharmacokinetics? Am I right? |
4 KudoZ points awarded for this answer.
Comment: "Thank you!!!!"
-1
8 mins
Veronica Prpic Uhing
United States
United States
Specializes in field
United States
Looking for something to translate!
Native in: Croatian
Works in: Croatian to English, English to Croatian, English to Bosnian, and 12 more.
Related KudoZ points
:
4
excreation
No metabolites or conjugates of metformin have been identified..
so it must be exreation
http://www.ncbi.nlm.nih.gov/pubmed/8743335
--------------------------------------------------
Note added at 9 mins (2008-01-31 15:51:39 GMT)
--------------------------------------------------
sorry
excretion
so it must be exreation
http://www.ncbi.nlm.nih.gov/pubmed/8743335
--------------------------------------------------
Note added at 9 mins (2008-01-31 15:51:39 GMT)
--------------------------------------------------
sorry
excretion
Peer comment(s):
| disagree |
liz askew
: No wonder it is difficult to understand the meaning of "disposition". This must be a back translation, your ref. is a translation from French.//It is more complicated than this.//It is NOT just "excreted"; the term is more involved than just this meaning
28 mins
|
|
It is pharmacokinetic term, Q: Is metmorfin disposed (eliminated) or bio transformed. The ref states that metmorfin has no metabolites and conjugates (biodegraded or biotransformed) – for research articles - http://www.ncbi.nlm.nih.gov/PubMed/
|
Something went wrong...