Aug 18, 2021 00:54
3 yrs ago
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English term
chimeric antigen receptor (CAR) T-cell therapy
GBK
English to Bulgarian
Medical
Medical (general)
Definition from
American Cancer Association:
Chimeric antigen receptor (CAR) T-cell therapy is a promising new way to get immune cells called T cells (a type of white blood cell) to fight cancer by changing them in the lab so they can find and destroy cancer cells. CAR T-cell therapies are sometimes talked about as a type of gene or cell therapy, or immune effect cell therapy.
Example sentences:
Chimeric antigen receptor (CAR) T-cell therapy has had great success in treating patients with relapsed or refractory B-cell malignancies, with CD19-targeting therapies now approved in many countries. However, a subset of patients fail to respond or relapse after CD19 CAR T-cell therapy, in part due to antigen loss, which has prompted the search for alternative antigen targets. (Research Square)
Chimeric antigen receptor (CAR) T-cell therapy represents a major advancement in personalized cancer treatment. In this strategy, a patient's own T cells are genetically engineered to express a synthetic receptor that binds a tumor antigen. CAR T cells are then expanded for clinical use and infused back into the patient's body to attack and destroy chemotherapy-resistant cancer. (PubMed)
In the past 5 years, knowledge of immunology in thoracic cancers has greatly improved. The results observed with immunotherapy are encouraging. For example, in patients with stage 4 non–small cell lung cancer, 5-year survival was previously 2%. That survival rate has now increased to approximately 20% with the use of checkpoint blockade immunotherapy. Similarly, early data from our trial combining chimeric antigen receptor (CAR) T-cell therapy and checkpoint blockade in mesothelioma were promising. (Hematology & Oncology)
Proposed translations
(Bulgarian)
5 | Терапия с t-клетки с химерен антигенен рецептор |
Mihail Mateev
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Change log
Aug 13, 2021 12:48: changed "Kudoz queue" from "In queue" to "Public"
Aug 18, 2021 00:54: changed "Stage" from "Preparation" to "Submission"
Aug 21, 2021 00:54: changed "Stage" from "Submission" to "Selection"
Aug 28, 2021 01:55:
Sep 17, 2021 01:55:
Oct 17, 2021 01:55:
Proposed translations
4 hrs
Терапия с t-клетки с химерен антигенен рецептор
Други възможни варианти за превод:
car t-клетъчна терапия
car t-клетъчна терапия
Definition from
https://medguide.bg:
Т-клетките с химерен антигенен рецептор представляват имунни клетки, които са генетично модифицирани да експресират синтетичен рецептор. Химерните антигенни рецептори (CARs) са протеини, насочващи Т-клетките към специфичен антиген. Наричат се химерни, тъй като комбинират както антиген-свързващи, така и Т-клетъчнo-активиращи функции.
Example sentences:
Abecma е генетично модифициран автоломен химерен антигенен рецептор (CAR) Т-клетъчна терапия и първата клетъчна генна терапия за лечение на възрастни пациенти с множествен миелом . Всяка доза Abecma се създава чрез събиране на собствени Т-клетки на пациента (т.е. бели кръвни клетки, които помагат на организма да се бори с инфекциите) и генетично ги модифицира, така че да включват нов ген, който помага на организма да насочи и убие клетките на миелома. След това тези модифицирани имунни клетки се вливат обратно в кръвта на пациента. (https://onconavigator.info)
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