English term
cytokine storm
Researchers aren’t sure what percentage of severely ill patients will die from a cytokine storm, or even why some people who are infected will go on to have this reaction, while others won’t (WebMD)
Like many other viruses, particularly SARS, MERS, and influenza, the cytokine storm has been used as a warning sign for clinicians to recognize disease escalation. (News Medical)
The combination of hyperinflammation, coagulopathy, and low platelet counts places patients with cytokine storm at high risk for spontaneous hemorrhage. (The New England Journal of Medicine)
5 | 细胞因子风暴 | Frank Feng |
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Proposed translations
细胞因子风暴
什么是细胞因子风暴? 正常模式下,病毒来袭,免疫反攻;病毒溃败,免疫收兵。但有些时候,免疫细胞大军失控,以服从命令为天职的士兵成了随心所欲的暴徒,拿着重量级武器横冲直撞。 这种免疫系统的“倒戈起义”,虽然已有检测手段、反击方法,但是对新冠病毒引发的免疫失常,具体应对手段还不很明确。 免疫系统反应过激的原因多种多样,包括感染、基因缺陷、“敌我混淆”(把自身组织看作入侵者)的免疫疾病等。所有这些都归入“细胞因子风暴”范畴。 (BBC)
炎症因子风暴也称细胞因子风暴(cytokine storm),或系统性炎症反应综合征(system inflammatory response syndrome, SIRS),其机制是免疫细胞过度的活化,细胞内炎性因子包括白细胞介素、TNF-a, 补体蛋白分子等大量释放,对感染源及被感染的细胞进行暴风雨般的自杀式攻击,造成自身组织细胞的旁观者损伤伴随血管通透性增加及循环障碍,最坏的结果是多器官功能衰竭(MOF)。 (中国免疫学会)
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