English term
affinity maturation
Collectively, structural studies of affinity maturation have shown that increased antibody affinity can arise from any one or any combination of multiple diverse mechanisms, including improved shape complementarity at the interface with antigen, increased buried surface area upon complex formation, additional interfacial polar or hydrophobic interactions, and preorganization or rigidification of the antigen-binding site. (Frontier in Immunology)
An understanding of how affinity maturation occurs at multiple stages of the antigen-driven B-cell immune response provides insights into the overall design of B-cell immune responses. (ScienceDirect)
We show how affinity maturation in this lineage has maintained adaptability (“breadth” of neutralizing activity) by generating a branched and, hence, diversifying phylogeny (PNAS)
| 4 | affiniteitsmaturatie |
Erik van Vliet
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Oct 3, 2020 00:42: changed "Kudoz queue" from "In queue" to "Public"
Oct 28, 2020 00:56: changed "Stage" from "Preparation" to "Submission"
Oct 31, 2020 01:57: changed "Stage" from "Submission" to "Selection"
Nov 7, 2020 01:54:
Nov 27, 2020 01:54:
Dec 27, 2020 03:09:
Proposed translations
Netherlands
M. Sc. Molecular Biology
Native in: Dutch 
Works in: English to Dutch, Dutch to English, Dutch
affiniteitsmaturatie
In de kiemcentra onstaan cycli van B-cel proliferatie en affiniteitsmaturatie gevolgd door selectie van die B-cellen die de hoogste affiniteit voor het betreffende antigeen hebben ontwikkeld. (Universiteit Groningen)
Pisciene B-cellen vertonen nauwelijks affiniteitsmaturatie (Voss et al., 1978; Arkoosh en Kaattari, 1991), hoewel somatische mutatie even frequent voorkomt als bij zoogdieren. (Universiteit Gent)
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