Glossary entry (derived from question below)
English term or phrase:
BTK Occupancy Sample
Russian translation:
образец для анализа занятости участков связывания ВТК (тирозинкиазы Брутона)
Added to glossary by
Margarita Vidkovskaia
Feb 16, 2017 11:39
7 yrs ago
3 viewers *
English term
BTK Occupancy Sample
English to Russian
Medical
Medical: Pharmaceuticals
Clinical Protocol, SCHEDULE OF TESTING
SPECIMEN &/OR RESULT MANAGEMENT
(Contracted by Sponsor)
PK Primary Sample
PK Back up Sample
Genotypingm
Gene Expressionq
***BTK Occupancy Sample***
(Contracted by Sponsor)
PK Primary Sample
PK Back up Sample
Genotypingm
Gene Expressionq
***BTK Occupancy Sample***
Proposed translations
(Russian)
4 | образец для анализа занятости участков связывания ВТК |
Natalie
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References
BTK = Bruton's tyrosine kinase |
Oleg Lozinskiy
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Proposed translations
11 mins
Selected
образец для анализа занятости участков связывания ВТК
ВТК - тирозинкиназа Брутона
4 KudoZ points awarded for this answer.
Comment: "Большое спасибо, Натали и Олег!"
Reference comments
15 mins
Reference:
BTK = Bruton's tyrosine kinase
Bruton’s tyrosine kinase (BTK) is a cytoplasmic protein found in all hematopoietic cell lineages except for T cells. BTK mediates signaling downstream of a number of receptors.
...
BTK occupancy assay
Primary AML cells and U937 were treated with increasing concentrations of ibrutinib (0.3-1000 nM) for 1 hour. Cells were then washed in phosphate-buffered saline and stored at −80°C until a BTK occupancy assay was performed as described.
...
First we established the level of occupancy of the BTK active site by ibrutinib in AML cells. To do this, we treated primary AML sample #22 and AML cell line U937 with increasing concentrations of ibrutinib (3-1000 nM) for 1 hour.
http://www.bloodjournal.org/content/123/8/1229?sso-checked=t...
...
BTK occupancy assay
Primary AML cells and U937 were treated with increasing concentrations of ibrutinib (0.3-1000 nM) for 1 hour. Cells were then washed in phosphate-buffered saline and stored at −80°C until a BTK occupancy assay was performed as described.
...
First we established the level of occupancy of the BTK active site by ibrutinib in AML cells. To do this, we treated primary AML sample #22 and AML cell line U937 with increasing concentrations of ibrutinib (3-1000 nM) for 1 hour.
http://www.bloodjournal.org/content/123/8/1229?sso-checked=t...
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