English to Spanish Science Biology (-tech,-chem,micro-) biochemistry

Saludos.
No se si sea correcto una traducción literal o tiene un nombre específico.
Gracias por su trabajo.



Bacillus subtilis: from soil bacterium to super-secreting cell factory

The Tat pathway is less well defined. It essentially consists of two components named TatA and TatC. A TatAC complex has been proposed to serve as the receptor for RRsignal peptides [25]. The TatC subunit then drives the membrane insertion of the signal peptide [26,27], and membrane translocation of the full precursor protein requires the association of the TatAC-precursor complex with additional oligomeric TatA complexes [25]. Intriguingly, while TatAC complexes represent the minimal translocases, the situation in B. subtilis is somewhat more complex as the TatA subunits have been triplicated, while the TatC subunits have been duplicated [25]. Recent studies indicate that °'mixed translocases'° including multiple Tat subunits may be active in B. subtilis [28-30]. While the B. subtilis Sec pathway is successfully employed for the production of heterologous secreted proteins, the Tat pathway of this organism remains to be unlocked for this purpose [31,32]. Opening the Tat pathway for secretory protein production is an interesting and potentially highly rewarding challenge for cell Factory engineering since this pathway can secrete proteins that have been fully folded in the cytoplasm, including enzyme complexes and proteins with bound cofactors [31,32]. The B. subtilis Tat machinery is intrinsically capable of this astonishing feat, but this is only evident when it is heterologously expressed in Escherichia coli [33,34]. In B. subtilis itself, this pathway is highly selective in the acceptance of substrates and the codes for this selectivity remain to be cracked [32,35]. Possibly, the key for opening Tat is to be found within the complex interaction network of which the Tat subunits are part. This network was recently shown to include several novel factors that are required for Tat-dependent protein translocation [30].