English to Russian Medical Medical: Pharmaceuticals

8A is an exemplary Western blot showing loss of the GILT tag after uptake. FIG. 8B is an exemplary Western blot showing processing of wild-type and GILT-tagged recombinant human acid glucosidase various peptide species after uptake.
The present invention provides methods for treating Pompe disease in a subject by administering to the subject a therapeutically effective amount of a fusion protein which includes human acid alpha-glucosidase (GAA), or a fragment thereof, and a lysosomal targeting domain.