This question was closed without grading. Reason: Other
Aug 27, 2009 13:36
15 yrs ago
English term
Peak/Through
English to Turkish
Medical
Medical: Pharmaceuticals
"It's a description of the variance in the drug PK profile. One of the purported advantages of Product M is that it is supposed to deliver a
smoother level of anticoagulation effect - less difference between peak drug in the body and trough - which may lead to less risk of side
effects such as bleeding. That's the story, anyway, and that's why the Apixaban team decided to opt for twice daily dosing to ensure a smoother PK curve, leading to a potential safety benefit, rather than once a day, which would start with
a larger bolus effect (potentially causing more bruising and bleeding) and then would taper off by the time 24 hours had passed (leaving the
patient at greater risk of stroke)"
smoother level of anticoagulation effect - less difference between peak drug in the body and trough - which may lead to less risk of side
effects such as bleeding. That's the story, anyway, and that's why the Apixaban team decided to opt for twice daily dosing to ensure a smoother PK curve, leading to a potential safety benefit, rather than once a day, which would start with
a larger bolus effect (potentially causing more bruising and bleeding) and then would taper off by the time 24 hours had passed (leaving the
patient at greater risk of stroke)"
Proposed translations
(Turkish)
5 | pik/taban | Kerem Severoğlu (X) |
5 | tepe/dip noktası | Selma Dogan |
4 | Tam/ara doz | Salih YILDIRIM |
Proposed translations
28 mins
pik/taban
pik zaten yaygın olarak kullanılıyor, taban ise pik kadar olmasa da grafikte konsantrasyonun en alt seviyeye ulaştığı bölgeyi belirtmek için kullanılıyor.
Ekteki linkte kullanımı görebilirsiniz.
Ekteki linkte kullanımı görebilirsiniz.
15 mins
Tam/ara doz
Böyle yorumluyorum.
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Note added at 40 mins (2009-08-27 14:17:07 GMT)
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Cinematography: Burada ne denilmektedir?
.......twice daily dosing to ensure a smoother PK curve,.....
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Note added at 40 mins (2009-08-27 14:17:07 GMT)
--------------------------------------------------
Cinematography: Burada ne denilmektedir?
.......twice daily dosing to ensure a smoother PK curve,.....
15 hrs
tepe/dip noktası
pik demek istemezseniz "tepe" de diyebilirsiniz. Ama Kerem beyin önerisi de uygun.
bu arada kaynak terim "through" değil "trough" olmalı.
http://www.tureng.com/search/trough to peak ratio
bu arada kaynak terim "through" değil "trough" olmalı.
http://www.tureng.com/search/trough to peak ratio
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