Dec 4, 2008 19:35
15 yrs ago
1 viewer *
English term
Degree + PhD in Dentistry, ATA-Certified
Native in: Italian 
Works in: English to Italian, Italian to English, Italian
Mean absolute improvement of trough FEV1 of 10-12% change
English
Medical
Medical (general)
Contex: Efficacy of a new drug
Primary endpoints compared to placebo
***Mean absolute improvement of trough FEV1 of 10-12% change from baseline (increase of 200-240mL)***
The above sentence is unclear to me.
In case I am missing something here, can you please rephrase/explain it for me?
Thank you in advance for your time
Primary endpoints compared to placebo
***Mean absolute improvement of trough FEV1 of 10-12% change from baseline (increase of 200-240mL)***
The above sentence is unclear to me.
In case I am missing something here, can you please rephrase/explain it for me?
Thank you in advance for your time
Responses
| 3 +2 | explanation |
Ken Cox
|
| 5 +1 | Please see explanation |
Jason Kang
|
Responses
+2
2 hrs
Selected
explanation
The basic meaning of the sentence is that the mean value (a specific sort of average) of the trough FEV1 was 10 to 12% better than the baseline (reference) value, which corresponded to an increase of 200 to 250 ml.
I'm not sure of the exact meaning of FEV1, but I suspect it has to to with respiration (ventilation), and the 'trough' probably refers to the minimum region of a curve ('dip') of a curve. In any case, this terminology is most likely standard in the field.
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Note added at 2 hrs (2008-12-04 21:52:49 GMT)
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sorry: 240 ml
I'm not sure of the exact meaning of FEV1, but I suspect it has to to with respiration (ventilation), and the 'trough' probably refers to the minimum region of a curve ('dip') of a curve. In any case, this terminology is most likely standard in the field.
--------------------------------------------------
Note added at 2 hrs (2008-12-04 21:52:49 GMT)
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sorry: 240 ml
Note from asker:
| Thanks. FEV1 means forced expiratory volume in one second ;) |
| Actually, thanks a lot!!! |
4 KudoZ points awarded for this answer.
Comment: "Thanks a lot. "
+1
1 hr
Jason Kang
Canada
Canada
Specializes in field
Canada
M.D. certified both from Korea and UK
Native in: Korean
Works in: English to Korean, Korean to English, Japanese to English, and 3 more.
Related KudoZ points
:
28
Please see explanation
Linked article says, 'Trough FEV1 (FVC) was defined as the mean FEV1 (FVC) approximately 24 hours after administration of study drug.'
Reference:
Note from asker:
| Many thanks nakcl. Have a nice one. |
Peer comment(s):
| agree |
redoktor
: or, maybe more precisely, before administration of the next dose
12 hrs
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Thanks!
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Discussion