Dec 20, 2021 06:04
2 yrs ago
18 viewers *
English term
debulking
English to Russian
Science
Biology (-tech,-chem,micro-)
The general steps for conventional manufacturing of a cell-based product, e.g., T cells, may include harvesting, debulking, and isolation, ex vivo manipulation,
Proposed translations
(Russian)
3 +1 | уменьшение объема |
Natalia Novichenko
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4 +1 | здесь: очистка клеточной массы |
Natalie
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3 | очистка |
Igor Andreev
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Change log
Dec 24, 2021 07:47: Natalia Novichenko Created KOG entry
Dec 24, 2021 08:04: Natalie changed "Removed from KOG" from "debulking > уменьшение объема by <a href="/profile/2526641">Natalia Novichenko</a>" to "Reason: Erroneous in this case"
Proposed translations
+1
1 hr
Selected
уменьшение объема
Уменьшение объема (суспензии/взвеси) собранных клеток. Достигается, например, центрифугированием.
В хирургии употребляется термин "дебалкинг" в отношении снижения объема поражения
В хирургии употребляется термин "дебалкинг" в отношении снижения объема поражения
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Comment: "Спасибо!"
+1
3 hrs
здесь: очистка клеточной массы
В этом конкретном контексте debulking означает очистку клеточной массы, удаление из нее всякого "мусора": мертвых клеток, клеточных обломков, примесей других видов клеток и т.п. Вот фраза, из которой все становится понятно:
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As tumour-infiltrating lymphocytes create only a small
fraction of tumour mass, we recommend to use the enrichment on
the density gradient as the initial step to fractionate distinctive populations and debulk the leukocytes of dead cells and tissue debris.
https://scrc-en.tbzmed.ac.ir/uploads/91/CMS/user/file/197/bo...
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As tumour-infiltrating lymphocytes create only a small
fraction of tumour mass, we recommend to use the enrichment on
the density gradient as the initial step to fractionate distinctive populations and debulk the leukocytes of dead cells and tissue debris.
https://scrc-en.tbzmed.ac.ir/uploads/91/CMS/user/file/197/bo...
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3 hrs
очистка
Похоже здесь это процедура отделения определенной клеточной популяции от других типов клеток. Близкие по значению термины: сортировка, выделение, обогащение клеточной популяции.
см. примеры использования в статье
https://pubs.rsc.org/en/content/articlelanding/2015/lc/c4lc0...
Cell sorting by MAP is usually performed to either debulk cell populations or to isolate rare cells from native biofluids
deterministic lateral displacement (a method described below) to debulk nucleated cells (e.g., leukocytes and CTCs) from erythrocytes and platelets
This concept was later used for debulking platelets from peripheral blood progenitor cells by Dykes et al.,106 for enriching prostate cancer cells from leukocytes by Augustsson et al.,107 and for sorting viable from non-viable cells by Yang et al.1
This label-free method of cell sorting has been used for debulking peripheral blood by removing erythrocytes from leukocytes, platelets, lipids, and plasma.
см. примеры использования в статье
https://pubs.rsc.org/en/content/articlelanding/2015/lc/c4lc0...
Cell sorting by MAP is usually performed to either debulk cell populations or to isolate rare cells from native biofluids
deterministic lateral displacement (a method described below) to debulk nucleated cells (e.g., leukocytes and CTCs) from erythrocytes and platelets
This concept was later used for debulking platelets from peripheral blood progenitor cells by Dykes et al.,106 for enriching prostate cancer cells from leukocytes by Augustsson et al.,107 and for sorting viable from non-viable cells by Yang et al.1
This label-free method of cell sorting has been used for debulking peripheral blood by removing erythrocytes from leukocytes, platelets, lipids, and plasma.
Discussion
Цитата из ссылки, приведенной Ириной
For bone marrow, peripheral and cord blood, and other liquid or semiliquid sources, debulking might be performed after harvest by physical property approaches such as density gradient centrifugation or elutriation. Separation methods based on physical properties generally have the capacity to process or debulk very large numbers of cells in a single step (e.g., 1–3 × 1010 input cells).
В этом контексте синонимом debulk является слово deplete ("обеднение"), вот пример:
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https://books.google.ru › books
Mary Clarke, Jonathan Frampton · 2020 · Science
... subsequently) in essence to deplete (“debulk”) the cell preparation of cells that have the potential to contaminate the sort and hence reduce purity.
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