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          • Term
            • housekeeping gene
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          • Definition(s)
            • A housekeeping gene is typically a constitutive gene that is required for the maintenance of basal cellular function, and are found in all human cells.[1][2] Although some housekeeping genes are expressed at relatively constant levels(such as HSP90 and Beta-actin), other housekeeping genes may vary depending on experimental conditions. Wikipedia
          • Example sentence(s)
            • Here, the non-regulation of seven housekeeping genes (beta-tubulin, cyclophilin, actin, elongation factor 1-alpha (ef1alpha), 18S rRNA, adenine phosphoribosyl transferase (aprt), and cytoplasmic ribosomal protein L2) during biotic (late blight) and abiotic stresses (cold and salt stress) was tested on potato plants using geNorm software. - National Center for Biotechnology Inform by
            • An inherent assumption in the use of housekeeping genes is that expression of the genes remains constant in the cells or tissues under investigation. Although exceptions to this assumption are well documented, housekeeping genes are of value in fully characterized systems. - American Physiological Society by
            • The researchers propose that many other housekeeping genes in addition to HPRT may also be found to regulate important developmental pathways. - MediLexicon International Ltd by
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    • German
      • Genetics
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          • Term
            • Haushaltsgen (Housekeeping-Gen)
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          • Definition(s)
            • Ein Haushaltsgen (auch englisch housekeeping gene, nicht-reguliertes Gen, konstitutiv exprimiertes Gen) ist ein Gen, welches unabhängig von Zelltyp, Zellstadium und äußeren Einflüssen exprimiert wird, im Gegensatz zu den regulierten Genen. Haushaltsgene sind typischerweise Gene, die mit dem Grundstoffwechsel von Zellen zusammenhängen, beispielsweise mit dem Glukose-Stoffwechsel. Im menschlichen Genom befinden sich etwa 10.000 Housekeeping-Gene. Wikipedia - by Marga Shaw
          • Example sentence(s)
            • Haushaltsgen, ein Gen, dessen Expression für das Funktionieren der meisten oder gar aller Zelltypen entscheidend ist. - Lexikon der Biologie by Marga Shaw
            • Die Klasse-II-Gene unterteilt man in regulierte und nicht-regulierte Gene. Die nicht-regulierten oder konstitutiv exprimierten Gene bezeichnet man auch als Housekeeping-Gene (siehe Abschnitt 1.2). - Disseration, HU Berlin by Marga Shaw
            • Ein Haushaltsgen zeichnet sich dadurch aus, dass es in allen Geweben und bzw. Zellen gleichmäßig exprimiert wird und es in seiner Expression nicht durch äußere Einflüsse reguliert wird. Bei der relativen Quantifizierung dient das Haushaltsgen zur Normalisierung und als endogene Kontrolle, gegen das alle Zielgene semiquantifiziert werden. Es sollte dabei möglichst ein ähnliches Expressionsniveau wie die zu untersuchenden Zielgene aufweisen. - Uni Lübeck by Marga Shaw
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    • Italian
      • Genetics
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          • Term
            • gene housekeeping
          • Additional fields of expertise
          • Definition(s)
            • Si definiscono geni housekeeping dei geni che vengono attivamente trascritti e tradotti ad un livello relativamente elevato. Generalmente, essi codificano per proteine ed enzimi fondamentali per la vita della cellula, e che pertanto devono essere sempre presenti. Wikipedia - by Serena Arduini
          • Example sentence(s)
            • Tuttavia, la selezione dei geni di controllo adatti può causare problemi poiché possono non essere espressi ugualmente attraverso tutti i campioni incogniti. Ciò può essere risolto normalizzando le misure con un insieme di geni housekeeping per evitare tale problema di variabilità. - Wikipedia - PCR Real Time by Serena Arduini
            • Verrà allestito un sistema di PCR quantitativa real-time su cDNA da retrotrascrizione per la quantificazione relativa dei livelli di espressione delle MEP, utilizzando come riferimento il livello di espressione di un gene housekeeping. - Ricerca italiana - PRIN by Serena Arduini
            • La reazione avviene in parallelo per il sistema relativo alla PMP22 e per un gene housekeeping sicuramente presente in copia singola nel genoma, nonché ubiquitariamente espresso. La presenza di quest’ultimo è fondamentale per l’analisi di quantizzazione in Real Time, poiché consente di avere un riferimento di numero di copie geniche. - Tesi - Gabrielli Livide by Serena Arduini
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