Nov 11, 2002 07:06
22 yrs ago
34 viewers *
Spanish term
creatinina
Spanish to English
Medical
medical exam
Proposed translations
(English)
| 5 +9 | creatinine |
Fernando Muela Sopeña
|
| 5 | creatinin |
Elena Sgarbo (X)
|
Proposed translations
+9
3 mins
Fernando Muela Sopeña
Spain
Spain
Native in Spanish
Spain
The passion for the right word
Native in: Spanish (Variant: Standard-Spain) 
Works in: French to Spanish, Russian to Spanish, Spanish
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251
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creatinine
Espero que te sirva.
Creatinine is a metabolic by product of muscle metabolism (it is derived from creatine and phosphocreatine). For the majority of patients the muscle turnover varies little from day to day, and the serum creatinine is more or less constant. Creatinine is filtered and excreted by the kidney. Serum creatinine is probably the most widely used indirect measure of glomerular filtration rate; it is easy and inexpensive to measure. But what about accuracy? Unfortunately, serum creatinine is very insensitive to even substantial declines in glomerular filtration rate. Glomerular filtration rate may be reduced by up to 50% before serum creatinine becomes elevated. This is due to a combination of increased extrarenal metabolism and secretion of this substance by the renal tubules. Creatinine overestimates the GFR. So it is difficult to assess true renal function using serum creatinine. Conventional wisdom relates that a doubling of the serum creatinine is indicative of renal failure.
The other major problem with creatinine in the intensive care unit is that physicians often do not look at the creatinine in the clinical context: a raised serum creatinine is inevitable in any patient involved in trauma, over-exertion, heat stroke or rhabdomyolysis. Moreover, a patient who has been critically ill for some time should have a reduced serum creatinine (due to loss of muscle mass associated with catabolism), a normal looking serum level may actually be indicative of very poor renal function.
Creatinine is a metabolic by product of muscle metabolism (it is derived from creatine and phosphocreatine). For the majority of patients the muscle turnover varies little from day to day, and the serum creatinine is more or less constant. Creatinine is filtered and excreted by the kidney. Serum creatinine is probably the most widely used indirect measure of glomerular filtration rate; it is easy and inexpensive to measure. But what about accuracy? Unfortunately, serum creatinine is very insensitive to even substantial declines in glomerular filtration rate. Glomerular filtration rate may be reduced by up to 50% before serum creatinine becomes elevated. This is due to a combination of increased extrarenal metabolism and secretion of this substance by the renal tubules. Creatinine overestimates the GFR. So it is difficult to assess true renal function using serum creatinine. Conventional wisdom relates that a doubling of the serum creatinine is indicative of renal failure.
The other major problem with creatinine in the intensive care unit is that physicians often do not look at the creatinine in the clinical context: a raised serum creatinine is inevitable in any patient involved in trauma, over-exertion, heat stroke or rhabdomyolysis. Moreover, a patient who has been critically ill for some time should have a reduced serum creatinine (due to loss of muscle mass associated with catabolism), a normal looking serum level may actually be indicative of very poor renal function.
4 KudoZ points awarded for this answer.
Comment: "Claro que me sirvió....con esta ya van 3 millones de gracias
Excellent references..."
4 hrs
creatinin
(last letter is an "n").
References from Medline:
Wijnen MH, Cuypers P, Buth J, Vader HL, Roumen RM. Differences in renal response between endovascular and open repair of abdominal aortic aneurysms.
OBJECTIVES: to determine the difference in renal and systemic response between open and endovascular aneurysm repair. MATERIALS AND METHODS: we studied prospectively 22 patients undergoing open repair (OR) and 15 patients undergoing endovascular repair (ER). Blood and urine samples were taken preoperatively (T0) and before clamping of the aorta or femoral artery (T1) and 5 min (T2), 1 h (T3), 6 h (T4), 24 h (Day 1) and 48 h (Day 2) after declamping. Albumin/creatinin ratio (AC ratio) in urine, serum albumin, serum **creatinin**, serum C-reactive protein and serum lactate were determined. RESULTS: the urinary AC ratio in ER was significantly lower than in OR (p<0.001). In both groups the rise in urine albumin/ **creatinin** ratio after declamping (T2, T3) was significant (p<0.001). C-reactive protein was raised significantly at day 1 and 2 in both groups (p<0.001) with no difference between the groups. Serum lactate values were significantly higher in OR. There was a significant increase in serum lactate 6 h after declamping in the ER group. CONCLUSIONS: after endovascular repair renal damage is less compared to open repair. There is a significant systemic reaction to the endovascular repair causing mild, short-lasting damage to the kidney. This systemic response is most probably induced by a combination of ischaemia reperfusion injury and the surgical trauma of the procedure. Other possible explanations are discussed.
Kordzaya DJ, Goderdzishvili VT. Pathogenesis of endotoxemia and multiple organ failure in case of mechanical jaundice and their aggravation after the relief of cholestasis.
Institute of Clinical and Experimental Surgery, Academy of Classical and Traditional Medicine, Tbilisi, Georgia.
PURPOSE: To clarify the mechanisms of systemic endotoxemia in extrahepatic cholestasis and the pathogenesis of aggravation of multiorgan failure after external biliary drainage (EBD)--for elaborating of the curative tactics. MATERIALS AND METHODS: The results of experimental studies performed on 208 Wistar rats and 90 dogs were implemented in the surgical clinic in treatment of 150 patients with cholestasis. In experiments--Histological, Transmission and Scanning Electron Microscopic, and Biochemical (Malonic Dialdehide--the end product of Peroxide Oxidation of Lipids of cell membrane) methods have been used. Perfect model of EBD in cholestasis was created. In clinic--the measurement of Mitochondrial ferments, Bilirubin concentration, **Creatinin** clearance and Psychometric tests were used for evaluation of liver, kidney and brain functions....
References from Medline:
Wijnen MH, Cuypers P, Buth J, Vader HL, Roumen RM. Differences in renal response between endovascular and open repair of abdominal aortic aneurysms.
OBJECTIVES: to determine the difference in renal and systemic response between open and endovascular aneurysm repair. MATERIALS AND METHODS: we studied prospectively 22 patients undergoing open repair (OR) and 15 patients undergoing endovascular repair (ER). Blood and urine samples were taken preoperatively (T0) and before clamping of the aorta or femoral artery (T1) and 5 min (T2), 1 h (T3), 6 h (T4), 24 h (Day 1) and 48 h (Day 2) after declamping. Albumin/creatinin ratio (AC ratio) in urine, serum albumin, serum **creatinin**, serum C-reactive protein and serum lactate were determined. RESULTS: the urinary AC ratio in ER was significantly lower than in OR (p<0.001). In both groups the rise in urine albumin/ **creatinin** ratio after declamping (T2, T3) was significant (p<0.001). C-reactive protein was raised significantly at day 1 and 2 in both groups (p<0.001) with no difference between the groups. Serum lactate values were significantly higher in OR. There was a significant increase in serum lactate 6 h after declamping in the ER group. CONCLUSIONS: after endovascular repair renal damage is less compared to open repair. There is a significant systemic reaction to the endovascular repair causing mild, short-lasting damage to the kidney. This systemic response is most probably induced by a combination of ischaemia reperfusion injury and the surgical trauma of the procedure. Other possible explanations are discussed.
Kordzaya DJ, Goderdzishvili VT. Pathogenesis of endotoxemia and multiple organ failure in case of mechanical jaundice and their aggravation after the relief of cholestasis.
Institute of Clinical and Experimental Surgery, Academy of Classical and Traditional Medicine, Tbilisi, Georgia.
PURPOSE: To clarify the mechanisms of systemic endotoxemia in extrahepatic cholestasis and the pathogenesis of aggravation of multiorgan failure after external biliary drainage (EBD)--for elaborating of the curative tactics. MATERIALS AND METHODS: The results of experimental studies performed on 208 Wistar rats and 90 dogs were implemented in the surgical clinic in treatment of 150 patients with cholestasis. In experiments--Histological, Transmission and Scanning Electron Microscopic, and Biochemical (Malonic Dialdehide--the end product of Peroxide Oxidation of Lipids of cell membrane) methods have been used. Perfect model of EBD in cholestasis was created. In clinic--the measurement of Mitochondrial ferments, Bilirubin concentration, **Creatinin** clearance and Psychometric tests were used for evaluation of liver, kidney and brain functions....
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