Glossary entry (derived from question below)
Italian term or phrase:
in acuto
English translation:
acute oral route
Added to glossary by
Joseph Tein
Jun 16, 2010 11:21
14 yrs ago
8 viewers *
Italian term
United States
Multilingual. Very careful & precise.
Native in: English 
Works in: Spanish to English, Italian to English
in acuto
Italian to English
Medical
Medical: Pharmaceuticals
drug tolerability studies
This expression has been asked before, and was answered by one of our very expert colleagues. I think this is a different context:
This is about a medication being tested in vitro and then in vivo in rats and monkeys. The article first talks about good tolerability at normal doses, then says: "A dosi piu' elevate, il XXX, somministrato per via orale **in acuto** in animali roditori e non roditori, provoca diarrea e convulsioni. "
What does "in acuto" mean here, and how do we say it in English in this context? What does it mean to administer a drug "in acuto" to experimental rats and monkeys and maybe a few bunnies?
(Is it maybe the opposite of chronic or long-term administration?)
This is about a medication being tested in vitro and then in vivo in rats and monkeys. The article first talks about good tolerability at normal doses, then says: "A dosi piu' elevate, il XXX, somministrato per via orale **in acuto** in animali roditori e non roditori, provoca diarrea e convulsioni. "
What does "in acuto" mean here, and how do we say it in English in this context? What does it mean to administer a drug "in acuto" to experimental rats and monkeys and maybe a few bunnies?
(Is it maybe the opposite of chronic or long-term administration?)
Proposed translations
(English)
| 4 +3 | acute oral route |
Lionel_M (X)
|
Proposed translations
+3
59 mins
Selected
acute oral route
http://www.google.fr/#hl=fr&q="acute oral route"&aq=f&aqi=&a...
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Note added at 1 ora (2010-06-16 12:43:48 GMT)
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Hi Joseph, in your particular sentence, you may decide for. "At higher doses, acute oral administration of XXXX in rodents ......
e.g.
Effect of acute oral administration of alcohol on superoxide anion ... - [ Traduire cette page ]
de C Libon - 1993 - Cité 14 fois - Autres articles
Journal of Leukocyte. Biology. Volume. 53, January. 1993. 93. Effect of acute oral administration of alcohol on superoxide ...
www.jleukbio.org/cgi/reprint/53/1/93.pdfAlterations in sperm motility after acute oral administration of ...
de G POMARA - 2007 - Cité 12 fois - Autres articles
Titre du document / Document title. Alterations in sperm motility after acute oral administration of sildenafil or tadalafil in young, infertile men ...
cat.inist.fr/?aModele=afficheN&cpsidt=19168979Acute oral administration of dehydroepiandrosterone in male ...
de G VALENTI - 1999 - Cité 4 fois - Autres articles
Acute oral administration of dehydroepiandrosterone in male subjects : Effect of age on bioavailability, sulfoconjugation and bioconversion in other ...
cat.inist.fr/?aModele=afficheN&cpsidt=1286714Plus de résultats de cat.inist.frEffects of acute oral administration of lithium compounds on ... - [ Traduire cette page ]
de DW Chrislip
Effects of acute oral administration of lithium compounds on multiple schedule performance in rats. Chrislip DW, Anger WK, Smith RJ. ...
www.ncbi.nlm.nih.gov/pubmed/2987718Some Biochemical Effects of Sub-Acute Oral Administration of L ... - [ Traduire cette page ]
Some Biochemical Effects of Sub-Acute Oral Administration of L-Arginine on Monosodium Glutamate-Fed Wistar Albino Rats 2: Serum Alkaline Phosphatase, ...
scialert.net/fulltext/?doi=ajb.2010.89.95&org=10 - En cache[PDF] Andersen 12_1_36-49 - [ Traduire cette page ]
Format de fichier: PDF/Adobe Acrobat - Afficher
de KIMF ANDERSEN - Autres articles
Effects of acute oral administration of 4 mg salbutamol on exercise performance in non-asthmatic elite athletes. JEPonline 2009;12(1):36-49. ...
faculty.css.edu/tboone2/asep/Andersen12_1_36-49.pdfCardiovascular and pulmonary response to oral administration of ... - [ Traduire cette page ]
de K Kichenin - 2000 - Cité 13 fois - Autres articles
Results presented herein indicate that acute oral administration of ATP has no effect on cardiac activity, vascular resistance, or respiratory parameters. ...
jap.physiology.org/cgi/content/full/88/6/1962Oral administration of a potent and selective non-peptidic BACE-1 ... - [ Traduire cette page ]
de I Hussain - 2007 - Cité 58 fois - Autres articles
transgenic mice, acute oral administration of GSK188909 in the presence of a p-glycoprotein inhibitor to markedly enhance the exposure of GSK188909 in the ...
www3.interscience.wiley.com/journal/118483731/articletext?DOI=10...Psychomotor performance in relation to acute oral administration ... - [ Traduire cette page ]
de P Roser - 2009 - Autres articles
ORIGINAL PAPER. Patrik Roser Æ Jürgen Gallinat Æ Gordon Weinberg Æ Georg Juckel Æ Inge Gorynia Æ Andreas M. Stadelmann. Psychomotor performance in relation ...
www.springerlink.com/index/X478XG8020M12301.pdfTissue-speci... induction of mutations by acute oral ... - [ Traduire cette page ]
de D Brault - 1996 - Cité 16 fois - Autres articles
Tissue-specific induction of mutations by acute oral administration of N-methyl-N′-nitro-N-nitrosoguanidine and β-propiolactone to the Muta™Mouse: ...
linkinghub.elsevier.com/retrieve/pii/0165116195000674 - Pages similaires
and some other 100.000 ghits :)
--------------------------------------------------
Note added at 1 ora (2010-06-16 12:43:48 GMT)
--------------------------------------------------
Hi Joseph, in your particular sentence, you may decide for. "At higher doses, acute oral administration of XXXX in rodents ......
e.g.
Effect of acute oral administration of alcohol on superoxide anion ... - [ Traduire cette page ]
de C Libon - 1993 - Cité 14 fois - Autres articles
Journal of Leukocyte. Biology. Volume. 53, January. 1993. 93. Effect of acute oral administration of alcohol on superoxide ...
www.jleukbio.org/cgi/reprint/53/1/93.pdfAlterations in sperm motility after acute oral administration of ...
de G POMARA - 2007 - Cité 12 fois - Autres articles
Titre du document / Document title. Alterations in sperm motility after acute oral administration of sildenafil or tadalafil in young, infertile men ...
cat.inist.fr/?aModele=afficheN&cpsidt=19168979Acute oral administration of dehydroepiandrosterone in male ...
de G VALENTI - 1999 - Cité 4 fois - Autres articles
Acute oral administration of dehydroepiandrosterone in male subjects : Effect of age on bioavailability, sulfoconjugation and bioconversion in other ...
cat.inist.fr/?aModele=afficheN&cpsidt=1286714Plus de résultats de cat.inist.frEffects of acute oral administration of lithium compounds on ... - [ Traduire cette page ]
de DW Chrislip
Effects of acute oral administration of lithium compounds on multiple schedule performance in rats. Chrislip DW, Anger WK, Smith RJ. ...
www.ncbi.nlm.nih.gov/pubmed/2987718Some Biochemical Effects of Sub-Acute Oral Administration of L ... - [ Traduire cette page ]
Some Biochemical Effects of Sub-Acute Oral Administration of L-Arginine on Monosodium Glutamate-Fed Wistar Albino Rats 2: Serum Alkaline Phosphatase, ...
scialert.net/fulltext/?doi=ajb.2010.89.95&org=10 - En cache[PDF] Andersen 12_1_36-49 - [ Traduire cette page ]
Format de fichier: PDF/Adobe Acrobat - Afficher
de KIMF ANDERSEN - Autres articles
Effects of acute oral administration of 4 mg salbutamol on exercise performance in non-asthmatic elite athletes. JEPonline 2009;12(1):36-49. ...
faculty.css.edu/tboone2/asep/Andersen12_1_36-49.pdfCardiovascular and pulmonary response to oral administration of ... - [ Traduire cette page ]
de K Kichenin - 2000 - Cité 13 fois - Autres articles
Results presented herein indicate that acute oral administration of ATP has no effect on cardiac activity, vascular resistance, or respiratory parameters. ...
jap.physiology.org/cgi/content/full/88/6/1962Oral administration of a potent and selective non-peptidic BACE-1 ... - [ Traduire cette page ]
de I Hussain - 2007 - Cité 58 fois - Autres articles
transgenic mice, acute oral administration of GSK188909 in the presence of a p-glycoprotein inhibitor to markedly enhance the exposure of GSK188909 in the ...
www3.interscience.wiley.com/journal/118483731/articletext?DOI=10...Psychomotor performance in relation to acute oral administration ... - [ Traduire cette page ]
de P Roser - 2009 - Autres articles
ORIGINAL PAPER. Patrik Roser Æ Jürgen Gallinat Æ Gordon Weinberg Æ Georg Juckel Æ Inge Gorynia Æ Andreas M. Stadelmann. Psychomotor performance in relation ...
www.springerlink.com/index/X478XG8020M12301.pdfTissue-speci... induction of mutations by acute oral ... - [ Traduire cette page ]
de D Brault - 1996 - Cité 16 fois - Autres articles
Tissue-specific induction of mutations by acute oral administration of N-methyl-N′-nitro-N-nitrosoguanidine and β-propiolactone to the Muta™Mouse: ...
linkinghub.elsevier.com/retrieve/pii/0165116195000674 - Pages similaires
and some other 100.000 ghits :)
4 KudoZ points awarded for this answer.
Comment: "Ciao Lionel ... merci beaucoup de ton aide!"
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