English to Russian Medical Medical: Pharmaceuticals

4. Cross-reactivity with cynomolgus monkey VEGF (with less than a log difference affinity as compared to humanVEGF) and neutralizing activity of VEGF binding to cynomolgus VEGF receptors is a must. Cross-reactivity with rodent VEGF (rat and/or mouse) and neutralizing activity of VEGF binding to rodent VEGF receptors (rat and/or mouse) is desirable but not nesessary.

5. Functional antagonistic antibody. The antagonistic properties to be shown in HUVEC Assay using Avastin (Lucentis) as a comparator antibody.

6. Highly specific binds to VEGF receptors. No unspecific binding to other epitopes (to the surface of unrelated human cell lines).