Aug 20 14:59
2 mos ago
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English term
bi-single
English to Polish
Science
Medical (general)
patenty
Examples of binding fragments ... (include):
1) a Fab fragment...
....
5) a signle domain antibody fragment
6) a bi-single domain antibody fragment
7)...
1) a Fab fragment...
....
5) a signle domain antibody fragment
6) a bi-single domain antibody fragment
7)...
Proposed translations
(Polish)
2 | bispecyficzne przeciwciało jednodomenowe | Frank Szmulowicz, Ph. D. |
Proposed translations
30 mins
bispecyficzne przeciwciało jednodomenowe
Declined
Bi-single domain antibody, also termed bispecific VHH single domain antibody (sdAb), is a derivative of camelid heavy chain antibody (hcAb). Unlike conventional https://www.creativebiolabs.net/bi-single-domain-antibody.ht...
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W przeciwieństwie do tego Carvykti wykorzystuje strukturę zwaną nanociałem, znaną również jako przeciwciało jednodomenowe (VHH) (patrz ryc. 1).
https://aktualnosci.news/terapia-car-t-radykalnie-zmniejsza-...
szpiczaka-mnogiego-391008/
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„Rozwój leku opartego o bispecyficzne przeciwciało do immunoterapii przeciwnowotworowej”
https://www.portalzp.pl/przetargi/rozwoj-leku-opartego-o-bis...
Jednak przeciwciała można również hodować w laboratorium i wytwarzać z dodatkowymi funkcjami. Bispecyficzne przeciwciało monoklonalne jest wytwarzane w laboratorium i ma dodatkową cechę. Podczas gdy naturalnie występujące przeciwciała są w stanie wiązać się tylko z jednym receptorem komórkowym – który jest bardzo specyficznym receptorem na określonej komórce; Bispecyficzne przeciwciała monoklonalne wiążą się ze specyficznymi receptorami na dwóch różnych komórkach
https://www.lymphoma.org.au/pl/immunoterapia/terapia-przeciw...
cccccccccccccccccccccccccccccc
W przeciwieństwie do tego Carvykti wykorzystuje strukturę zwaną nanociałem, znaną również jako przeciwciało jednodomenowe (VHH) (patrz ryc. 1).
https://aktualnosci.news/terapia-car-t-radykalnie-zmniejsza-...
szpiczaka-mnogiego-391008/
ccc
„Rozwój leku opartego o bispecyficzne przeciwciało do immunoterapii przeciwnowotworowej”
https://www.portalzp.pl/przetargi/rozwoj-leku-opartego-o-bis...
Jednak przeciwciała można również hodować w laboratorium i wytwarzać z dodatkowymi funkcjami. Bispecyficzne przeciwciało monoklonalne jest wytwarzane w laboratorium i ma dodatkową cechę. Podczas gdy naturalnie występujące przeciwciała są w stanie wiązać się tylko z jednym receptorem komórkowym – który jest bardzo specyficznym receptorem na określonej komórce; Bispecyficzne przeciwciała monoklonalne wiążą się ze specyficznymi receptorami na dwóch różnych komórkach
https://www.lymphoma.org.au/pl/immunoterapia/terapia-przeciw...
Note from asker:
czy to na pewno przeciwciało jednodomenowe? "5) a single domain antibody (dAb) fragment, which consists of a VH domain; 6) a bi-single domain antibody which consists of two VH domains linked by a hinge (dual-affinity re-targeting antibodies (DARTs) |
Reference comments
28 mins
Reference:
bi-single domain antibody
Bi-single Domain Antibody
Creative Biolabs possesses unchallenged experience in bi-single domain antibody synthesis. Multiple platforms of Creative Biolabs are elaborately integrated for providing customers an expected bi-single domain antibody with high affinity and low immunogenicity for both academic and industrial purposes.
Bi-single domain antibody, also termed bispecific VHH single domain antibody (sdAb), is a derivative of camelid heavy chain antibody (hcAb). Unlike conventional mammal antibody which consists of two pairs of chains, hcAb has only one pair of heavy chains with constant domain and variable domain (VHH), and the bi-single domain antibody is only consisted of the VHHs. The loss of light chain and constant fragment in bi-single domain antibody does not eliminate its functional antigen-binding capacity, but even endows it unsubstitutable advantage in application. One fifth of convential antibody molecular weight (~150 kDa) makes bi-single domain antibody (~30 kDa) perform much better in penetrating tissue, binding antigen, recognizing epitope, enduring physical and chemical impact. Additionally, we can also link a bi-single domain antibody to an albumin to generate HSA-bi-single domain antibody, which has a longer half-life and improved bio-distribution.
Diagram of a bi-single domain antibody structureFigure: Diagram of a bi-single domain antibody structure
Beside the outstanding advantages of sdAb, bi-single domain antibody also possesses the unique potential for therapeutic application as bispecific antibody. Hence, Creative Biolabs makes itself a qualified bi-single domain antibody producer with rich experience in bi-single domain antibody field.
And Our Renowned Protein Engineering platform is very suitable for vector construction, protein expression and antibody purification. Furthermore, Sensitive Immunogenicity Assessment Technology® (SIAT) platform can also promise our customer not only a pure bi-single domain antibody product, but also a reliable research tool with effect and safety.
Creative Biolabs possesses unchallenged experience in bi-single domain antibody synthesis. Multiple platforms of Creative Biolabs are elaborately integrated for providing customers an expected bi-single domain antibody with high affinity and low immunogenicity for both academic and industrial purposes.
Bi-single domain antibody, also termed bispecific VHH single domain antibody (sdAb), is a derivative of camelid heavy chain antibody (hcAb). Unlike conventional mammal antibody which consists of two pairs of chains, hcAb has only one pair of heavy chains with constant domain and variable domain (VHH), and the bi-single domain antibody is only consisted of the VHHs. The loss of light chain and constant fragment in bi-single domain antibody does not eliminate its functional antigen-binding capacity, but even endows it unsubstitutable advantage in application. One fifth of convential antibody molecular weight (~150 kDa) makes bi-single domain antibody (~30 kDa) perform much better in penetrating tissue, binding antigen, recognizing epitope, enduring physical and chemical impact. Additionally, we can also link a bi-single domain antibody to an albumin to generate HSA-bi-single domain antibody, which has a longer half-life and improved bio-distribution.
Diagram of a bi-single domain antibody structureFigure: Diagram of a bi-single domain antibody structure
Beside the outstanding advantages of sdAb, bi-single domain antibody also possesses the unique potential for therapeutic application as bispecific antibody. Hence, Creative Biolabs makes itself a qualified bi-single domain antibody producer with rich experience in bi-single domain antibody field.
And Our Renowned Protein Engineering platform is very suitable for vector construction, protein expression and antibody purification. Furthermore, Sensitive Immunogenicity Assessment Technology® (SIAT) platform can also promise our customer not only a pure bi-single domain antibody product, but also a reliable research tool with effect and safety.
Discussion