English to Russian Medical Medical: Pharmaceuticals Toxicology written summar

Spindle disturbances in V79 cells with and without expression of human CYP1A2
Spindle disturbing effects in terms of c-mitosis and cytotoxicity of paracetamol were investigated in two Chinese hamster V79 cell lines, one of which (V79MZh1A2) was transfected with human cytochrome (CY) P1A2.
The present study demonstrated that paracetamol may disturb the spindle of dividing cells conveying a risk of aneuploidy.
The spindle disturbing effect was only slightly enhanced by expression of CYP1A2, suggesting that metabolic activation plays only a minor role in this genotoxic effect.
Relationship between the concentration of paracetamol in 2 hour exposure and genotoxic effects in terms of spindle disturbances measured by c-mitosis frequency in a native V79 cell line (▲) and a V79 cell line expressing human CYP1A2 (O)