Glossary entry (derived from question below)
English term or phrase:
genome-wide expression profiling approach
Spanish translation:
aproximación a la determinación de la expresión hologenómica/pangenómica
Added to glossary by
Jorge Arteaga M.D.
May 4, 2016 17:27
8 yrs ago
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English term
genome-wide expression profiling approach
English to Spanish
Medical
Genetics
En un artículo titulado "Selective Inhibition of Inflammatory Gene Expression in Activated T Lymphocytes: A Mechanism of Immune Suppression by Thiopurines":
"Since the therapeutic immunosuppression of AZA and 6-MP is evident in the setting of chronic inflammatory diseases, but usually does not predispose to opportunistic infections, we reasoned that these drugs act by selectively affecting activated but not resting immune cells. To test this possibility, we developed an in vitro system of AZA-treated T lymphocytes that models closely the effects of AZA therapy on those cells in vivo. Using a **genome-wide expression profiling approach**, we evaluated the effects of AZA on the expression of genes in both resting and stimulated T lymphocytes. Our results have identified several immune and inflammation-related genes whose up-regulated expression is potently inhibited by thiopurines in activated but not resting T lymphocytes, suggesting potential novel immunosuppressive mechanisms of these drugs."
genome-wide indica "relación con todo el genoma o el ADN completo de un individuo" [Navarro] y se traduce "hologenómico" (Navarro) o "pangenómico" (Igea). Hasta los momentos he colocado "método de elaboración de perfiles de expresión pangenómica", pero no sé si está correcto.
Muchísimas gracias por adelantado
"Since the therapeutic immunosuppression of AZA and 6-MP is evident in the setting of chronic inflammatory diseases, but usually does not predispose to opportunistic infections, we reasoned that these drugs act by selectively affecting activated but not resting immune cells. To test this possibility, we developed an in vitro system of AZA-treated T lymphocytes that models closely the effects of AZA therapy on those cells in vivo. Using a **genome-wide expression profiling approach**, we evaluated the effects of AZA on the expression of genes in both resting and stimulated T lymphocytes. Our results have identified several immune and inflammation-related genes whose up-regulated expression is potently inhibited by thiopurines in activated but not resting T lymphocytes, suggesting potential novel immunosuppressive mechanisms of these drugs."
genome-wide indica "relación con todo el genoma o el ADN completo de un individuo" [Navarro] y se traduce "hologenómico" (Navarro) o "pangenómico" (Igea). Hasta los momentos he colocado "método de elaboración de perfiles de expresión pangenómica", pero no sé si está correcto.
Muchísimas gracias por adelantado
Proposed translations
(Spanish)
4 | aproximación a la determinación de la expresión hologenómica/pangenómica | Jorge Arteaga M.D. |
Change log
May 16, 2016 13:58: Jorge Arteaga M.D. Created KOG entry
Proposed translations
25 mins
Selected
aproximación a la determinación de la expresión hologenómica/pangenómica
Your translation "método de elaboración de perfiles de expresión pangenómica" sounds good to me, but I believe here profiling refers to determining the expression and I like it better.
Saludos...
Saludos...
4 KudoZ points awarded for this answer.
Comment: "Muchas gracias"
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